(3R,11bR)-3-{2-[(S)-6,7-Dimethoxy-2-(2-phenoxy-benzyl)-1,2,3,4-tetrahydro-isoquinolin-1-yl]-ethyl}-9,10-dimethoxy-1,3,4,6,7,11b-hexahydro-2H-pyrido[2,1-a]isoquinoline

Base Information

• Chemical Name: (3R,11bR)-3-{2-[(S)-6,7-Dimethoxy-2-(2-phenoxy-benzyl)-1,2,3,4-tetrahydro-isoquinolin-1-yl]-ethyl}-9,10-dimethoxy-1,3,4,6,7,11b-hexahydro-2H-pyrido[2,1-a]isoquinoline
• CAS No.: 143951-59-1
• Molecular Formula: C₄₁H₄₈N₂O₅
• Molecular Weight: 648.843

Synonyms:

Chemical Property of (3R,11bR)-3-{2-[(S)-6,7-Dimethoxy-2-(2-phenoxy-benzyl)-1,2,3,4-tetrahydro-isoquinolin-1-yl]-ethyl}-9,10-dimethoxy-1,3,4,6,7,11b-hexahydro-2H-pyrido[2,1-a]isoquinoline

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Technology Process of (3R,11bR)-3-{2-[(S)-6,7-Dimethoxy-2-(2-phenoxy-benzyl)-1,2,3,4-tetrahydro-isoquinolin-1-yl]-ethyl}-9,10-dimethoxy-1,3,4,6,7,11b-hexahydro-2H-pyrido[2,1-a]isoquinoline

There total 60 articles about (3R,11bR)-3-{2-[(S)-6,7-Dimethoxy-2-(2-phenoxy-benzyl)-1,2,3,4-tetrahydro-isoquinolin-1-yl]-ethyl}-9,10-dimethoxy-1,3,4,6,7,11b-hexahydro-2H-pyrido[2,1-a]isoquinoline which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

{(S)-1-[2-((3R,11bS)-9,10-Dimethoxy-1,3,4,6,7,11b-hexahydro-2H-pyrido[2,1-a]isoquinolin-3-yl)-ethyl]-6,7-dimethoxy-3,4-dihydro-1H-isoquinolin-2-yl}-(2-phenoxy-phenyl)-methanone (143951-58-0,144016-52-4,144016-53-5,144016-54-6) → (3R,11bS)-3-{2-[(S)-6,7-Dimethoxy-2-(2-phenoxy-benzyl)-1,2,3,4-tetrahydro-isoquinolin-1-yl]-ethyl}-9,10-dimethoxy-1,3,4,6,7,11b-hexahydro-2H-pyrido[2,1-a]isoquinoline (143951-59-1,144016-55-7,144016-56-8,144016-57-9)

Guidance literature:

With dimethylsulfide borane complex; In tetrahydrofuran; for 4.5h; Heating;

DOI:10.1248/cpb.40.1390

Reference yield: 95.0%

{(S)-1-[2-((3R,11bR)-9,10-Dimethoxy-1,3,4,6,7,11b-hexahydro-2H-pyrido[2,1-a]isoquinolin-3-yl)-ethyl]-6,7-dimethoxy-3,4-dihydro-1H-isoquinolin-2-yl}-(2-phenoxy-phenyl)-methanone (143951-58-0,144016-52-4,144016-53-5,144016-54-6) → (3R,11bR)-3-{2-[(S)-6,7-Dimethoxy-2-(2-phenoxy-benzyl)-1,2,3,4-tetrahydro-isoquinolin-1-yl]-ethyl}-9,10-dimethoxy-1,3,4,6,7,11b-hexahydro-2H-pyrido[2,1-a]isoquinoline (143951-59-1,144016-55-7,144016-56-8,144016-57-9)

Guidance literature:

With dimethylsulfide borane complex; In tetrahydrofuran; for 4.5h; Heating;

DOI:10.1248/cpb.40.1390

Reference yield: 91.0%

{(S)-1-[2-((3S,11bR)-9,10-Dimethoxy-1,3,4,6,7,11b-hexahydro-2H-pyrido[2,1-a]isoquinolin-3-yl)-ethyl]-6,7-dimethoxy-3,4-dihydro-1H-isoquinolin-2-yl}-(2-phenoxy-phenyl)-methanone (143951-58-0,144016-52-4,144016-53-5,144016-54-6) → (3S,11bR)-3-{2-[(S)-6,7-Dimethoxy-2-(2-phenoxy-benzyl)-1,2,3,4-tetrahydro-isoquinolin-1-yl]-ethyl}-9,10-dimethoxy-1,3,4,6,7,11b-hexahydro-2H-pyrido[2,1-a]isoquinoline (143951-59-1,144016-55-7,144016-56-8,144016-57-9)

Guidance literature:

With dimethylsulfide borane complex; In tetrahydrofuran; for 4.5h; Heating;

DOI:10.1248/cpb.40.1390

upstream raw materials:

{(S)-1-[2-((3S,11bS)-9,10-Dimethoxy-1,3,4,6,7,11b-hexahydro-2H-pyrido[2,1-a]isoquinolin-3-yl)-ethyl]-6,7-dimethoxy-3,4-dihydro-1H-isoquinolin-2-yl}-(2-phenoxy-phenyl)-methanone

2-(3,4-dimethoxyphenyl)-ethylamine

4,4-bis(ethoxycarbonyl)butanoyl chloride

ethyl 1,3,4,6,7,11b-hexahydro-9,10-dimethoxy-4-oxo-2H-benzoquinolizine-3-carboxylate

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