4-{1-[5-(4-chloro-phenyl)-oxazol-2-yl]-1-methyl-ethyl}-1-[5-(2,2-dimethyl-3a,9b-dihydro-4H-chromeno[4,3-d]oxazol-1-yl)-2-hydroxy-5-oxo-4-thieno[3,2-c]pyridin-2-ylmethyl-pentyl]-piperazine-2-carboxylic acid (2,2,2-trifluoro-ethyl)-amide

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Chemical Name:4-{1-[5-(4-chloro-phenyl)-oxazol-2-yl]-1-methyl-ethyl}-1-[5-(2,2-dimethyl-3a,9b-dihydro-4H-chromeno[4,3-d]oxazol-1-yl)-2-hydroxy-5-oxo-4-thieno[3,2-c]pyridin-2-ylmethyl-pentyl]-piperazine-2-carboxylic acid (2,2,2-trifluoro-ethyl)-amide
CAS No.:870774-03-1
Molecular Formula:C₄₄H₄₈ClF₃N₆O₆S
Molecular Weight:881.416
Hs Code.:

4-{1-[5-(4-chloro-phenyl)-oxazol-2-yl]-1-methyl-ethyl}-1-[5-(2,2-dimethyl-3a,9b-dihydro-4<i>H</i>-chromeno[4,3-<i>d</i>]oxazol-1-yl)-2-hydroxy-5-oxo-4-thieno[3,2-<i>c</i>]pyridin-2-ylmethyl-pentyl]-piperazine-2-carboxylic acid (2,2,2-trifluoro-ethyl)-amide

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Chemical Property of 4-{1-[5-(4-chloro-phenyl)-oxazol-2-yl]-1-methyl-ethyl}-1-[5-(2,2-dimethyl-3a,9b-dihydro-4H-chromeno[4,3-d]oxazol-1-yl)-2-hydroxy-5-oxo-4-thieno[3,2-c]pyridin-2-ylmethyl-pentyl]-piperazine-2-carboxylic acid (2,2,2-trifluoro-ethyl)-amide

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Technology Process of 4-{1-[5-(4-chloro-phenyl)-oxazol-2-yl]-1-methyl-ethyl}-1-[5-(2,2-dimethyl-3a,9b-dihydro-4H-chromeno[4,3-d]oxazol-1-yl)-2-hydroxy-5-oxo-4-thieno[3,2-c]pyridin-2-ylmethyl-pentyl]-piperazine-2-carboxylic acid (2,2,2-trifluoro-ethyl)-amide

There total 9 articles about 4-{1-[5-(4-chloro-phenyl)-oxazol-2-yl]-1-methyl-ethyl}-1-[5-(2,2-dimethyl-3a,9b-dihydro-4H-chromeno[4,3-d]oxazol-1-yl)-2-hydroxy-5-oxo-4-thieno[3,2-c]pyridin-2-ylmethyl-pentyl]-piperazine-2-carboxylic acid (2,2,2-trifluoro-ethyl)-amide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 33.0%

: 870774-02-0
1-(2,2-dimethyl-3a,9b-dihydro-4H-chromeno[4,3-d]oxazol-1-yl)-2-oxiranylmethyl-3-thieno[3,2-c]pyridin-2-yl-propan-1-one

: (S)-4-{1-[5-(4-Chloro-phenyl)-oxazol-2-yl]-1-methyl-ethyl}-piperazine-2-carboxylic acid (2,2,2-trifluoro-ethyl)-amide

: 870774-03-1
4-{1-[5-(4-chloro-phenyl)-oxazol-2-yl]-1-methyl-ethyl}-1-[5-(2,2-dimethyl-3a,9b-dihydro-4H-chromeno[4,3-d]oxazol-1-yl)-2-hydroxy-5-oxo-4-thieno[3,2-c]pyridin-2-ylmethyl-pentyl]-piperazine-2-carboxylic acid (2,2,2-trifluoro-ethyl)-amide

Guidance literature:: In isopropyl alcohol; Heating;
DOI:10.1016/j.bmcl.2005.08.072

Reference yield:

: 94226-19-4
thieno[3,2-c]pyridine-2-carbaldehyde

: 870774-03-1
4-{1-[5-(4-chloro-phenyl)-oxazol-2-yl]-1-methyl-ethyl}-1-[5-(2,2-dimethyl-3a,9b-dihydro-4H-chromeno[4,3-d]oxazol-1-yl)-2-hydroxy-5-oxo-4-thieno[3,2-c]pyridin-2-ylmethyl-pentyl]-piperazine-2-carboxylic acid (2,2,2-trifluoro-ethyl)-amide

Guidance literature:: Multi-step reaction with 8 steps

1.1: 92 percent / NaH / tetrahydrofuran / 0 °C

2.1: H₂ / Pd/C / methanol / 20 °C

3.1: aq. NaOH / methanol

4.1: EDC; HOBt; Et₃N / CH₂Cl₂ / 20 °C

5.1: 10-camphorsulfonic acid / CH₂Cl₂

6.1: LiN(TMS)2 / tetrahydrofuran / -25 °C

6.2: 75 percent / tetrahydrofuran

7.1: NIS; aq. NaHCO₃ / ethyl acetate / 0 - 20 °C

7.2: 58 percent / NaOMe / ethyl acetate / 20 °C

8.1: 33 percent / propan-2-ol / Heating

With sodium hydroxide; N-iodo-succinimide; (1S)-10-camphorsulfonic acid; hydrogen; sodium hydride; sodium hydrogencarbonate; benzotriazol-1-ol; N-(3-dimethylaminopropyl)-N-ethylcarbodiimide; triethylamine; lithium hexamethyldisilazane; palladium on activated charcoal; In tetrahydrofuran; methanol; dichloromethane; ethyl acetate; isopropyl alcohol; 1.1: Wittig-Horner reaction;
DOI:10.1016/j.bmcl.2005.08.072

Reference yield:

: 3-thieno[3,2-c]pyridin-2-yl-acrylic acid ethyl ester

: 870774-03-1
4-{1-[5-(4-chloro-phenyl)-oxazol-2-yl]-1-methyl-ethyl}-1-[5-(2,2-dimethyl-3a,9b-dihydro-4H-chromeno[4,3-d]oxazol-1-yl)-2-hydroxy-5-oxo-4-thieno[3,2-c]pyridin-2-ylmethyl-pentyl]-piperazine-2-carboxylic acid (2,2,2-trifluoro-ethyl)-amide

Guidance literature:: Multi-step reaction with 7 steps

1.1: H₂ / Pd/C / methanol / 20 °C

2.1: aq. NaOH / methanol

3.1: EDC; HOBt; Et₃N / CH₂Cl₂ / 20 °C

4.1: 10-camphorsulfonic acid / CH₂Cl₂

5.1: LiN(TMS)2 / tetrahydrofuran / -25 °C

5.2: 75 percent / tetrahydrofuran

6.1: NIS; aq. NaHCO₃ / ethyl acetate / 0 - 20 °C

6.2: 58 percent / NaOMe / ethyl acetate / 20 °C

7.1: 33 percent / propan-2-ol / Heating

With sodium hydroxide; N-iodo-succinimide; (1S)-10-camphorsulfonic acid; hydrogen; sodium hydrogencarbonate; benzotriazol-1-ol; N-(3-dimethylaminopropyl)-N-ethylcarbodiimide; triethylamine; lithium hexamethyldisilazane; palladium on activated charcoal; In tetrahydrofuran; methanol; dichloromethane; ethyl acetate; isopropyl alcohol;
DOI:10.1016/j.bmcl.2005.08.072