Cyclo(Tyr-Leu)

Base Information

• Chemical Name: Cyclo(Tyr-Leu)
• CAS No.: 82863-65-8
• Molecular Formula: C₁₅H₂₀N₂O₃
• Molecular Weight: 276.335
• Mol file: 82863-65-8.mol

Synonyms:

Chemical Property of Cyclo(Tyr-Leu)

Chemical Property:

Purity/Quality:

HPLC≥98% ^*data from raw suppliers

Cyclo(Tyr-Leu) ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of Cyclo(Tyr-Leu)

There total 8 articles about Cyclo(Tyr-Leu) which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 83.0%

L-leucinyl-L-tyrosine methyl ester hydrochloride (26307-85-7) → 3-(4-hydroxybenzyl)-6-isobutylpiperazine-2,5-dione (15266-78-1,15266-87-2,82863-65-8)

Guidance literature:

With water; triethylamine; at 140 ℃; for 0.166667h; microwave irradiation;

DOI:10.1016/j.tet.2006.05.010

Reference yield:

N-tret-butoxycarbonyl-L-leucinyl-L-tyrosine methyl ester (18658-65-6) → 3-(4-hydroxybenzyl)-6-isobutylpiperazine-2,5-dione (15266-78-1,15266-87-2,82863-65-8)

Guidance literature:

Multi-step reaction with 2 steps

1: 94 percent / HCl / methanol / 5 h / 20 °C

2: 83 percent / water; triethylamine / 0.17 h / 140 °C / microwave irradiation

With hydrogenchloride; water; triethylamine; In methanol;

DOI:10.1016/j.tet.2006.05.010

Reference yield:

N-tert-butoxycarbonyl-L-leucine (13139-15-6,53296-34-7) → 3-(4-hydroxybenzyl)-6-isobutylpiperazine-2,5-dione (15266-78-1,15266-87-2,82863-65-8)

Guidance literature:

Multi-step reaction with 3 steps

1: 91 percent / 1-(3-dimethylaminopropyl)-3-ethylcarbodiimide; NMM / CH₂Cl₂ / 0 - 20 °C

2: 94 percent / HCl / methanol / 5 h / 20 °C

3: 83 percent / water; triethylamine / 0.17 h / 140 °C / microwave irradiation

With 4-methyl-morpholine; hydrogenchloride; water; N-(3-dimethylaminopropyl)-N-ethylcarbodiimide; triethylamine; In methanol; dichloromethane;

DOI:10.1016/j.tet.2006.05.010

upstream raw materials:

H-Leu-Tyr-OH

L-leucinyl-L-tyrosine methyl ester hydrochloride

N-tert-butoxycarbonyl-L-leucine

L-Tyr-OMe