Technology Process of PF-05180999
There total 10 articles about PF-05180999 which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
With
potassium carbonate;
bis(η3-allyl-μ-chloropalladium(II));
In
1,4-dioxane; dichloromethane;
at 102 ℃;
for 36h;
Inert atmosphere;
- Guidance literature:
-
Multi-step reaction with 8 steps
1.1: pyridinium perbromide hydrobromide / dichloromethane; ethanol / 3 h / 20 °C
2.1: N-ethyl-N,N-diisopropylamine / 1,2-dimethoxyethane; 2-methyltetrahydrofuran / 2.5 h / Cooling with ice; Reflux
3.1: dichloromethane / 2.5 h / 20 °C
4.1: iso-butanol / 3 h / 100 °C
5.1: tetrahydrofuran / 2.5 h / 65 °C
6.1: trichlorophosphate / acetonitrile / 0.17 h / 0 - 15 °C
6.2: 0.25 h / 41 - 48 °C
6.3: 1 h / 41 - 73 °C
7.1: triethylamine / acetonitrile / 1.33 h / 18 - 38 °C
8.1: potassium carbonate / bis(η3-allyl-μ-chloropalladium(II)) / dichloromethane; 1,4-dioxane / 36 h / 102 °C / Inert atmosphere
With
pyridinium perbromide hydrobromide; potassium carbonate; triethylamine; N-ethyl-N,N-diisopropylamine; trichlorophosphate;
bis(η3-allyl-μ-chloropalladium(II));
In
tetrahydrofuran; 2-methyltetrahydrofuran; 1,4-dioxane; 1,2-dimethoxyethane; ethanol; dichloromethane; acetonitrile; iso-butanol;
- Guidance literature:
-
Multi-step reaction with 7 steps
1.1: N-ethyl-N,N-diisopropylamine / 1,2-dimethoxyethane; 2-methyltetrahydrofuran / 2.5 h / Cooling with ice; Reflux
2.1: dichloromethane / 2.5 h / 20 °C
3.1: iso-butanol / 3 h / 100 °C
4.1: tetrahydrofuran / 2.5 h / 65 °C
5.1: trichlorophosphate / acetonitrile / 0.17 h / 0 - 15 °C
5.2: 0.25 h / 41 - 48 °C
5.3: 1 h / 41 - 73 °C
6.1: triethylamine / acetonitrile / 1.33 h / 18 - 38 °C
7.1: potassium carbonate / bis(η3-allyl-μ-chloropalladium(II)) / dichloromethane; 1,4-dioxane / 36 h / 102 °C / Inert atmosphere
With
potassium carbonate; triethylamine; N-ethyl-N,N-diisopropylamine; trichlorophosphate;
bis(η3-allyl-μ-chloropalladium(II));
In
tetrahydrofuran; 2-methyltetrahydrofuran; 1,4-dioxane; 1,2-dimethoxyethane; dichloromethane; acetonitrile; iso-butanol;
