5-(2-cyclohexylnaphthalen-1-yl)-[1,2,4]triazolo[4,3-b]isoquinoline

Base Information

Chemical Name:5-(2-cyclohexylnaphthalen-1-yl)-[1,2,4]triazolo[4,3-b]isoquinoline
CAS No.:1394249-34-3
Molecular Formula:C₂₆H₂₃N₃
Molecular Weight:377.489
Hs Code.:

Synonyms:

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Chemical Property of 5-(2-cyclohexylnaphthalen-1-yl)-[1,2,4]triazolo[4,3-b]isoquinoline

Chemical Property:

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Technology Process of 5-(2-cyclohexylnaphthalen-1-yl)-[1,2,4]triazolo[4,3-b]isoquinoline

There total 4 articles about 5-(2-cyclohexylnaphthalen-1-yl)-[1,2,4]triazolo[4,3-b]isoquinoline which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1374113-97-9
2-cyclohexylnaphthalen-1-ylboronic acid

: 1394249-34-3,1394367-99-7,1394368-00-3
5-(2-cyclohexylnaphthalen-1-yl)-[1,2,4]triazolo[4,3-b]isoquinoline

Guidance literature:: Multi-step reaction with 5 steps

1: tetrakis(triphenylphosphine) palladium⁽⁰⁾; cesium fluoride / 1,2-dimethoxyethane / Reflux

2: 1,1'-bis-(diphenylphosphino)ferrocene; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; caesium carbonate / toluene / Inert atmosphere; Reflux

3: hydrogenchloride / water; 1,4-dioxane / 20 °C / Inert atmosphere

4: water; 1,4-dioxane / 24 h / Reflux; Inert atmosphere

5: trichlorophosphate / toluene / 24 h / Reflux; Inert atmosphere

With hydrogenchloride; 1,1'-bis-(diphenylphosphino)ferrocene; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; tetrakis(triphenylphosphine) palladium⁽⁰⁾; caesium carbonate; cesium fluoride; trichlorophosphate; In 1,4-dioxane; 1,2-dimethoxyethane; water; toluene; 1: |Suzuki Coupling / 2: |Buchwald-Hartwig Coupling;
DOI:10.1021/ja3065446

Reference yield:

: 1092940-22-1
1-bromo-2-cyclohexylnaphthalene

: 1394249-34-3,1394367-99-7,1394368-00-3
5-(2-cyclohexylnaphthalen-1-yl)-[1,2,4]triazolo[4,3-b]isoquinoline

Guidance literature:: Multi-step reaction with 7 steps

1.1: magnesium; iodine / tetrahydrofuran / 2 h / -78 °C / Reflux; Inert atmosphere

1.2: -78 - 20 °C

2.1: hydrogenchloride / tetrahydrofuran; water

3.1: tetrakis(triphenylphosphine) palladium⁽⁰⁾; cesium fluoride / 1,2-dimethoxyethane / Reflux

4.1: 1,1'-bis-(diphenylphosphino)ferrocene; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; caesium carbonate / toluene / Inert atmosphere; Reflux

5.1: hydrogenchloride / water; 1,4-dioxane / 20 °C / Inert atmosphere

6.1: water; 1,4-dioxane / 24 h / Reflux; Inert atmosphere

7.1: trichlorophosphate / toluene / 24 h / Reflux; Inert atmosphere

With hydrogenchloride; 1,1'-bis-(diphenylphosphino)ferrocene; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; tetrakis(triphenylphosphine) palladium⁽⁰⁾; iodine; caesium carbonate; magnesium; cesium fluoride; trichlorophosphate; In tetrahydrofuran; 1,4-dioxane; 1,2-dimethoxyethane; water; toluene; 3.1: |Suzuki Coupling / 4.1: |Buchwald-Hartwig Coupling;
DOI:10.1021/ja3065446

Reference yield:

: C₂₅H₂₅N₃

: 1394249-34-3,1394367-99-7,1394368-00-3
5-(2-cyclohexylnaphthalen-1-yl)-[1,2,4]triazolo[4,3-b]isoquinoline

Guidance literature:: Multi-step reaction with 2 steps

1: water; 1,4-dioxane / 24 h / Reflux; Inert atmosphere

2: trichlorophosphate / toluene / 24 h / Reflux; Inert atmosphere

With trichlorophosphate; In 1,4-dioxane; water; toluene;
DOI:10.1021/ja3065446