Technology Process of methyl (3S,4S)-3-benzyloxy-4-methyloctanoate
There total 5 articles about methyl (3S,4S)-3-benzyloxy-4-methyloctanoate which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
Multi-step reaction with 5 steps
1: p-TsOH / CH2Cl2 / 2.5 h / Ambient temperature
2: 87 percent / DIBAL / toluene / 3 h / -52 - 20 °C
3: 1.) oxalyl chloride, DMSO, 2.) Et3N / 1.) CH2Cl2, -72 deg C, 10 min, 2.) CH2Cl2, from -72 deg C to RT, 45 min
4: KMnO4, phosphate buffer pH 7 / H2O; 2-methyl-propan-2-ol / 0.42 h / Ambient temperature
5: hexane; methanol
With
potassium permanganate; oxalyl dichloride; phosphate buffer pH 7; diisobutylaluminium hydride; toluene-4-sulfonic acid; dimethyl sulfoxide; triethylamine;
In
methanol; hexane; dichloromethane; water; toluene; tert-butyl alcohol;
DOI:10.1246/bcsj.66.3041
- Guidance literature:
-
Multi-step reaction with 4 steps
1: 87 percent / DIBAL / toluene / 3 h / -52 - 20 °C
2: 1.) oxalyl chloride, DMSO, 2.) Et3N / 1.) CH2Cl2, -72 deg C, 10 min, 2.) CH2Cl2, from -72 deg C to RT, 45 min
3: KMnO4, phosphate buffer pH 7 / H2O; 2-methyl-propan-2-ol / 0.42 h / Ambient temperature
4: hexane; methanol
With
potassium permanganate; oxalyl dichloride; phosphate buffer pH 7; diisobutylaluminium hydride; dimethyl sulfoxide; triethylamine;
In
methanol; hexane; water; toluene; tert-butyl alcohol;
DOI:10.1246/bcsj.66.3041
- Guidance literature:
-
Multi-step reaction with 2 steps
1: KMnO4, phosphate buffer pH 7 / H2O; 2-methyl-propan-2-ol / 0.42 h / Ambient temperature
2: hexane; methanol
With
potassium permanganate; phosphate buffer pH 7;
In
methanol; hexane; water; tert-butyl alcohol;
DOI:10.1246/bcsj.66.3041
