2-METHYL-5-(TRIFLUOROMETHYL)PHENYLACETIC ACID

Base Information

• Chemical Name: 2-METHYL-5-(TRIFLUOROMETHYL)PHENYLACETIC ACID
• CAS No.: 1000517-01-0
• Molecular Formula: C₁₀H₉F₃O₂
• Molecular Weight: 218.175
• Hs Code.: 2916399090
• Mol file: 1000517-01-0.mol

Synonyms:

Chemical Property of 2-METHYL-5-(TRIFLUOROMETHYL)PHENYLACETIC ACID

Chemical Property:

Purity/Quality:

99% ^*data from raw suppliers

2-Methyl-5-(trifluoromethyl)phenylacetic acid ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 2-METHYL-5-(TRIFLUOROMETHYL)PHENYLACETIC ACID

There total 2 articles about 2-METHYL-5-(TRIFLUOROMETHYL)PHENYLACETIC ACID which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

2-(2-methyl-5-(trifluoromethyl)phenyl)acetonitrile → 2-(2-methyl-5-(trifluoromethyl)phenyl)acetic acid (1000517-01-0)

Guidance literature:

With hydrogenchloride; sulfuric acid; sodium nitrite; In water; at 70 ℃; for 2h;

Reference yield:

2-(bromomethyl)-1-methyl-4-(trifluoromethyl)benzene (261952-17-4) → 2-(2-methyl-5-(trifluoromethyl)phenyl)acetic acid (1000517-01-0)

Guidance literature:

Multi-step reaction with 2 steps

1: N,N-dimethyl-formamide / 12 h / 15 °C

2: hydrogenchloride; sulfuric acid; sodium nitrite / water / 2 h / 70 °C

With hydrogenchloride; sulfuric acid; sodium nitrite; In water; N,N-dimethyl-formamide;

Reference yield:

2-(2-methyl-5-(trifluoromethyl)phenyl)acetic acid (1000517-01-0) → 2-(2-methyl-5(trifluoromethyl)phenyl)ethanol

Guidance literature:

With lithium aluminium tetrahydride; In tetrahydrofuran; at 0 - 20 ℃;

DOI:10.1080/14756366.2018.1513926

upstream raw materials:

2-(bromomethyl)-1-methyl-4-(trifluoromethyl)benzene

Refernces