Technology Process of (2R,3S,6S,7R)-8-[1,3]Dithian-2-yl-7-(4-methoxy-benzyloxy)-2,6-dimethyl-octane-1,3-diol
There total 18 articles about (2R,3S,6S,7R)-8-[1,3]Dithian-2-yl-7-(4-methoxy-benzyloxy)-2,6-dimethyl-octane-1,3-diol which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
Multi-step reaction with 16 steps
1: PPTS / CH2Cl2
2: K2CO3, MeOH
3: NaH, Bu4NI / tetrahydrofuran
4: 83 percent / n-BuLi / tetrahydrofuran / -78 - 0 °C
5: 1) AD-mix-α, 2) DMAP, DCC / 1) H2O, t-BuOH, 0 deg C, 2) CH2Cl2
6: CF3SO3H / tetrahydrofuran
7: 2 M NaOH / ethanol
8: CBr4, PPh3 / CH2Cl2
9: n-BuLi / tetrahydrofuran / -30 °C
10: PPTS, MeOH
11: DMAP / pyridine
12: K2CO3 / methanol
13: (i-PrO)3Al / toluene / 120 °C
14: Et3N, DMAP / CH2Cl2
15: 1) 9-BBN, 2) H2O2, 2 M NaOH / 1) THF, -78 to 50 deg C, 2) THF
16: LiAlH4 / tetrahydrofuran
With
methanol; dmap; sodium hydroxide; AD-mix-α; lithium aluminium tetrahydride; 9-borabicyclo[3.3.1]nonane dimer; n-butyllithium; carbon tetrabromide; trifluorormethanesulfonic acid; dihydrogen peroxide; pyridinium p-toluenesulfonate; aluminum isopropoxide; tetra-(n-butyl)ammonium iodide; sodium hydride; potassium carbonate; triethylamine; dicyclohexyl-carbodiimide; triphenylphosphine;
In
tetrahydrofuran; pyridine; methanol; ethanol; dichloromethane; toluene;
DOI:10.1246/cl.1997.117
- Guidance literature:
-
Multi-step reaction with 11 steps
1: CF3SO3H / tetrahydrofuran
2: 2 M NaOH / ethanol
3: CBr4, PPh3 / CH2Cl2
4: n-BuLi / tetrahydrofuran / -30 °C
5: PPTS, MeOH
6: DMAP / pyridine
7: K2CO3 / methanol
8: (i-PrO)3Al / toluene / 120 °C
9: Et3N, DMAP / CH2Cl2
10: 1) 9-BBN, 2) H2O2, 2 M NaOH / 1) THF, -78 to 50 deg C, 2) THF
11: LiAlH4 / tetrahydrofuran
With
methanol; dmap; sodium hydroxide; lithium aluminium tetrahydride; 9-borabicyclo[3.3.1]nonane dimer; n-butyllithium; carbon tetrabromide; trifluorormethanesulfonic acid; dihydrogen peroxide; pyridinium p-toluenesulfonate; aluminum isopropoxide; potassium carbonate; triethylamine; triphenylphosphine;
In
tetrahydrofuran; pyridine; methanol; ethanol; dichloromethane; toluene;
DOI:10.1246/cl.1997.117
- Guidance literature:
-
Multi-step reaction with 14 steps
1: NaH, Bu4NI / tetrahydrofuran
2: 83 percent / n-BuLi / tetrahydrofuran / -78 - 0 °C
3: 1) AD-mix-α, 2) DMAP, DCC / 1) H2O, t-BuOH, 0 deg C, 2) CH2Cl2
4: CF3SO3H / tetrahydrofuran
5: 2 M NaOH / ethanol
6: CBr4, PPh3 / CH2Cl2
7: n-BuLi / tetrahydrofuran / -30 °C
8: PPTS, MeOH
9: DMAP / pyridine
10: K2CO3 / methanol
11: (i-PrO)3Al / toluene / 120 °C
12: Et3N, DMAP / CH2Cl2
13: 1) 9-BBN, 2) H2O2, 2 M NaOH / 1) THF, -78 to 50 deg C, 2) THF
14: LiAlH4 / tetrahydrofuran
With
methanol; dmap; sodium hydroxide; AD-mix-α; lithium aluminium tetrahydride; 9-borabicyclo[3.3.1]nonane dimer; n-butyllithium; carbon tetrabromide; trifluorormethanesulfonic acid; dihydrogen peroxide; pyridinium p-toluenesulfonate; aluminum isopropoxide; tetra-(n-butyl)ammonium iodide; sodium hydride; potassium carbonate; triethylamine; dicyclohexyl-carbodiimide; triphenylphosphine;
In
tetrahydrofuran; pyridine; methanol; ethanol; dichloromethane; toluene;
DOI:10.1246/cl.1997.117
