N-{9-[(2R,3R,4S,5R)-5-[Bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-3-hydroxy-4-(tetrahydro-pyran-2-yloxy)-tetrahydro-furan-2-yl]-6-oxo-6,9-dihydro-1H-purin-2-yl}-isobutyramide

Base Information

Chemical Name:N-{9-[(2R,3R,4S,5R)-5-[Bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-3-hydroxy-4-(tetrahydro-pyran-2-yloxy)-tetrahydro-furan-2-yl]-6-oxo-6,9-dihydro-1H-purin-2-yl}-isobutyramide
CAS No.:132840-54-1
Molecular Formula:C₄₀H₄₅N₅O₉
Molecular Weight:739.825
Hs Code.:

N-{9-[(2R,3R,4S,5R)-5-[Bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-3-hydroxy-4-(tetrahydro-pyran-2-yloxy)-tetrahydro-furan-2-yl]-6-oxo-6,9-dihydro-1H-purin-2-yl}-isobutyramide

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Chemical Property of N-{9-[(2R,3R,4S,5R)-5-[Bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-3-hydroxy-4-(tetrahydro-pyran-2-yloxy)-tetrahydro-furan-2-yl]-6-oxo-6,9-dihydro-1H-purin-2-yl}-isobutyramide

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Technology Process of N-{9-[(2R,3R,4S,5R)-5-[Bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-3-hydroxy-4-(tetrahydro-pyran-2-yloxy)-tetrahydro-furan-2-yl]-6-oxo-6,9-dihydro-1H-purin-2-yl}-isobutyramide

There total 7 articles about N-{9-[(2R,3R,4S,5R)-5-[Bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-3-hydroxy-4-(tetrahydro-pyran-2-yloxy)-tetrahydro-furan-2-yl]-6-oxo-6,9-dihydro-1H-purin-2-yl}-isobutyramide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 110-87-2
3,4-dihydro-2H-pyran

: 132840-54-1
N-{9-[(2R,3R,4S,5R)-5-[Bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-3-hydroxy-4-(tetrahydro-pyran-2-yloxy)-tetrahydro-furan-2-yl]-6-oxo-6,9-dihydro-1H-purin-2-yl}-isobutyramide

Guidance literature:: Multi-step reaction with 3 steps

2: 1 M Et₃NHF / tetrahydrofuran

3: pyridine

With pyridine; triethylamine hydrofluoride; In tetrahydrofuran;

Reference yield:

: 64350-24-9
N²-isobutyryl-2'-deoxyguanosine

: 132840-54-1
N-{9-[(2R,3R,4S,5R)-5-[Bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-3-hydroxy-4-(tetrahydro-pyran-2-yloxy)-tetrahydro-furan-2-yl]-6-oxo-6,9-dihydro-1H-purin-2-yl}-isobutyramide

Guidance literature:: Multi-step reaction with 5 steps

1: p-TsOH*H₂O / dimethylformamide

2: Et₃N, 4-dimethylaminopyridine / CH₂Cl₂ / 0.25 h

4: 1 M Et₃NHF / tetrahydrofuran

5: pyridine

With pyridine; dmap; toluene-4-sulfonic acid; triethylamine hydrofluoride; triethylamine; In tetrahydrofuran; dichloromethane; N,N-dimethyl-formamide;

Reference yield:

: Acetic acid (3aR,4R,6R,6aR)-6-(2-isobutyrylamino-6-oxo-1,6-dihydro-purin-9-yl)-2-methoxy-2-methyl-tetrahydro-furo[3,4-d][1,3]dioxol-4-ylmethyl ester

: 132840-54-1
N-{9-[(2R,3R,4S,5R)-5-[Bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-3-hydroxy-4-(tetrahydro-pyran-2-yloxy)-tetrahydro-furan-2-yl]-6-oxo-6,9-dihydro-1H-purin-2-yl}-isobutyramide

Guidance literature:: Multi-step reaction with 3 steps

2: 1 M Et₃NHF / tetrahydrofuran

3: pyridine

With pyridine; triethylamine hydrofluoride; In tetrahydrofuran;