Diacerein IMpurity F

Base Information

• Chemical Name: Diacerein IMpurity F
• CAS No.: 13928-72-8
• Molecular Formula: C₃₅H₃₆O₁₆
• Molecular Weight: 712.661
• Mol file: 13928-72-8.mol

Synonyms:

Chemical Property of Diacerein IMpurity F

Chemical Property:

• Melting Point: 129-130 °C
• Boiling Point: 743.7±60.0 °C(Predicted)
• Density: 1.40±0.1 g/cm3(Predicted)
• Storage Temp.: -20°C Freezer, Under inert atmosphere
• Solubility.: Chloroform (Slightly), DMSO (Slightly)

Purity/Quality:

99.90% ^*data from raw suppliers

10-?β-?D-?Glucopyranosyl-?1,?8-?dihydroxy-?3-?(hydroxymethyl)?-anthroneheptaacetate ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

• Uses: 10-?β-?D-?Glucopyranosyl-?1,?8-?dihydroxy-?3-?(hydroxymethyl)?-anthrone heptaacetate is an impurity of Diacerein (D303000), a diacetyl derivative of Rhein (R318500). Demonstrates anti-arthritic activity without inhibiting prostaglandin synthesis.

Technology Process of Diacerein IMpurity F

There total 5 articles about Diacerein IMpurity F which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

acetic anhydride (108-24-7) → 1,8-diacetoxy-3-acetoxymethyl-10-(tetra-O-acetyl-ξ-D-glucopyranosyl)-anthrone (13928-72-8)

Guidance literature:

With zinc(II) chloride;

Reference yield:

1,8-dihydroxy-3-(hydroxymethyl)-9(10H)-anthracenone (6247-99-0) → 1,8-diacetoxy-3-acetoxymethyl-10-(tetra-O-acetyl-ξ-D-glucopyranosyl)-anthrone (13928-72-8)

Guidance literature:

Multi-step reaction with 2 steps

1: aq. NaOH solution; acetone / unter Ausschluss von Licht und Luft

2: zinc chloride

With sodium hydroxide; acetone; zinc(II) chloride;

Reference yield:

2,3,4,6-tetra-O-acetyl-α-D-glucopyranosyl bromide (572-09-8) → 1,8-diacetoxy-3-acetoxymethyl-10-(tetra-O-acetyl-ξ-D-glucopyranosyl)-anthrone (13928-72-8)

Guidance literature:

Multi-step reaction with 2 steps

1: aq. NaOH solution; acetone / unter Ausschluss von Licht und Luft

2: zinc chloride

With sodium hydroxide; acetone; zinc(II) chloride;

upstream raw materials:

acetic anhydride

1,8-dihydroxy-3-(hydroxymethyl)-9(10H)-anthracenone

2,3,4,6-tetra-O-acetyl-α-D-glucopyranosyl bromide