(E)-1-methoxy-3,3-dimethyl-4-(p-methoxyphenyl)-5,5-diphenyl-1-pentene

Base Information

• Chemical Name: (E)-1-methoxy-3,3-dimethyl-4-(p-methoxyphenyl)-5,5-diphenyl-1-pentene
• CAS No.: 104394-38-9
• Molecular Formula: C₂₇H₃₀O₂
• Molecular Weight: 386.534
• Mol file: 104394-38-9.mol

Synonyms:

Chemical Property of (E)-1-methoxy-3,3-dimethyl-4-(p-methoxyphenyl)-5,5-diphenyl-1-pentene

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (E)-1-methoxy-3,3-dimethyl-4-(p-methoxyphenyl)-5,5-diphenyl-1-pentene

There total 7 articles about (E)-1-methoxy-3,3-dimethyl-4-(p-methoxyphenyl)-5,5-diphenyl-1-pentene which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

2,2-diphenyl-2-(p-methoxyphenyl)ethanol (104394-32-3) → (E)-1-methoxy-3,3-dimethyl-4-(p-methoxyphenyl)-5,5-diphenyl-1-pentene (104394-38-9)

Guidance literature:

Multi-step reaction with 6 steps

1: 87 percent / pyridinium chlorochromate / CH₂Cl₂ / 2 h

2: 59 percent / zinc / benzene / 36 h / Heating

3: 97 percent / ammonia, lithium / tetrahydrofuran / 2 h / Heating

4: 81 percent / lithium aluminum hydride / tetrahydrofuran / 10 h / Heating

5: 87 percent / pyridinium chlorochromate / CH₂Cl₂ / 1.5 h

6: 1.) potassium tert-butoxide / 1.) THF, 0 deg C, 2.0 h, 2.) THF, RT, 5.0 h

With lithium aluminium tetrahydride; potassium tert-butylate; ammonia; lithium; pyridinium chlorochromate; zinc; In tetrahydrofuran; dichloromethane; benzene;

DOI:10.1021/jo00374a022

Reference yield:

2,2-diphenyl-2-(p-methoxyphenyl)acetaldehyde (104394-34-5) → (E)-1-methoxy-3,3-dimethyl-4-(p-methoxyphenyl)-5,5-diphenyl-1-pentene (104394-38-9)

Guidance literature:

Multi-step reaction with 5 steps

1: 59 percent / zinc / benzene / 36 h / Heating

2: 97 percent / ammonia, lithium / tetrahydrofuran / 2 h / Heating

3: 81 percent / lithium aluminum hydride / tetrahydrofuran / 10 h / Heating

4: 87 percent / pyridinium chlorochromate / CH₂Cl₂ / 1.5 h

5: 1.) potassium tert-butoxide / 1.) THF, 0 deg C, 2.0 h, 2.) THF, RT, 5.0 h

With lithium aluminium tetrahydride; potassium tert-butylate; ammonia; lithium; pyridinium chlorochromate; zinc; In tetrahydrofuran; dichloromethane; benzene;

DOI:10.1021/jo00374a022

Reference yield:

methyl 2,2-diphenyl-2-(p-methoxyphenyl) acetate (104394-33-4) → (E)-1-methoxy-3,3-dimethyl-4-(p-methoxyphenyl)-5,5-diphenyl-1-pentene (104394-38-9)

Guidance literature:

Multi-step reaction with 7 steps

1: 95 percent / lithium aluminum hydride / diethyl ether / 2 h / Heating

2: 87 percent / pyridinium chlorochromate / CH₂Cl₂ / 2 h

3: 59 percent / zinc / benzene / 36 h / Heating

4: 97 percent / ammonia, lithium / tetrahydrofuran / 2 h / Heating

5: 81 percent / lithium aluminum hydride / tetrahydrofuran / 10 h / Heating

6: 87 percent / pyridinium chlorochromate / CH₂Cl₂ / 1.5 h

7: 1.) potassium tert-butoxide / 1.) THF, 0 deg C, 2.0 h, 2.) THF, RT, 5.0 h

With lithium aluminium tetrahydride; potassium tert-butylate; ammonia; lithium; pyridinium chlorochromate; zinc; In tetrahydrofuran; diethyl ether; dichloromethane; benzene;

DOI:10.1021/jo00374a022

upstream raw materials:

(methoxymethyl)triphenylphosphonium chloride

2,2-dimethyl-3-(p-methoxyphenyl)-4,4-diphenylbutanal

2,2-diphenyl-2-(p-methoxyphenyl)ethanol

2,2-diphenyl-2-(p-methoxyphenyl)acetaldehyde