(1S,2R,3S)-(+)-3-tert-butylcyclohexene oxide

Base Information

• Chemical Name: (1S,2R,3S)-(+)-3-tert-butylcyclohexene oxide
• CAS No.: 271248-33-0
• Molecular Formula: C₁₀H₁₈O
• Molecular Weight: 154.252
• Mol file: 271248-33-0.mol

Synonyms:

Chemical Property of (1S,2R,3S)-(+)-3-tert-butylcyclohexene oxide

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (1S,2R,3S)-(+)-3-tert-butylcyclohexene oxide

There total 1 articles about (1S,2R,3S)-(+)-3-tert-butylcyclohexene oxide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

(+/-)-cis-3-tert-butyl-1,2-epoxycyclohexane (81800-94-4) → (1R,2S,3R)-(-)-3-tert-butylcyclohexene oxide (81800-95-5) + (1S,2R,3S)-(+)-3-tert-butylcyclohexene oxide (271248-33-0) + (1S,6S)-(+)-6-tert-butyl-2-cyclohexenol (40523-68-0,40523-69-1,51036-52-3) + (1R,6R)-(-)-6-tert-butyl-2-cyclohexenol

Guidance literature:

With 1,8-diazabicyclo[5.4.0]undec-7-ene; Lithium (S)-2-(1-pyrrolidinylmethyl)pyrrolidide; In tetrahydrofuran; at 20 ℃; for 16h;

DOI:10.3987/COM-99-S122

Reference yield: 5.0%

(1S,2R,3S)-(+)-3-tert-butylcyclohexene oxide (271248-33-0) → (1R,2R,6S)-2-Bromo-6-tert-butyl-cyclohexanol (38512-64-0) + t-2-bromo-c-3-tert-butyl-r-1-cyclohexanol (81801-07-2)

Guidance literature:

With hydrogen bromide; In chloroform; Ambient temperature;

DOI:10.1021/jo00137a015

Reference yield:

(1S,2R,3S)-(+)-3-tert-butylcyclohexene oxide (271248-33-0) → (2S,6R)-(+)-trans-2-bromo-6-tert-butylcyclohexanone (81801-05-0)

Guidance literature:

With jones reagent; hydrogen bromide; Multistep reaction; 1.) CHCl₃;

DOI:10.1021/jo00137a015

upstream raw materials:

(+/-)-cis-3-tert-butyl-1,2-epoxycyclohexane

Downstream raw materials:

(1R,2R,6S)-2-Bromo-6-tert-butyl-cyclohexanol

t-2-bromo-c-3-tert-butyl-r-1-cyclohexanol

(2S,6R)-(+)-trans-2-bromo-6-tert-butylcyclohexanone