9-<2'-deoxy-5'-O-(4,4'-dimethoxytrityl)-β-D-threo-pentofuranosyl>-N⁶-<(dimethylamino)methylidene>adenine 3'-<(2-cyanoethyl) N,N-diisopropylphosphoramidite>

Base Information

• Chemical Name: 9-<2'-deoxy-5'-O-(4,4'-dimethoxytrityl)-β-D-threo-pentofuranosyl>-N⁶-<(dimethylamino)methylidene>adenine 3'-<(2-cyanoethyl) N,N-diisopropylphosphoramidite>
• CAS No.: 139260-85-8
• Molecular Formula: C₄₃H₅₃N₈O₆P
• Molecular Weight: 808.918

Synonyms:

Chemical Property of 9-<2'-deoxy-5'-O-(4,4'-dimethoxytrityl)-β-D-threo-pentofuranosyl>-N⁶-<(dimethylamino)methylidene>adenine 3'-<(2-cyanoethyl) N,N-diisopropylphosphoramidite>

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 9-<2'-deoxy-5'-O-(4,4'-dimethoxytrityl)-β-D-threo-pentofuranosyl>-N⁶-<(dimethylamino)methylidene>adenine 3'-<(2-cyanoethyl) N,N-diisopropylphosphoramidite>

There total 3 articles about 9-<2'-deoxy-5'-O-(4,4'-dimethoxytrityl)-β-D-threo-pentofuranosyl>-N⁶-<(dimethylamino)methylidene>adenine 3'-<(2-cyanoethyl) N,N-diisopropylphosphoramidite> which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

4,4'-dimethoxytrityl chloride (40615-36-9) → 9-<2'-deoxy-5'-O-(4,4'-dimethoxytrityl)-β-D-threo-pentofuranosyl>-N6-<(dimethylamino)methylidene>adenine 3'-<(2-cyanoethyl) N,N-diisopropylphosphoramidite> (139260-85-8,149572-85-0,149572-86-1)

Guidance literature:

Multi-step reaction with 2 steps

1: pyridine, (i-Pr)2EtN / 3.5 h / Ambient temperature

2: 96 percent / tetrahydrofuran / 0.5 h / Ambient temperature

With pyridine; N-ethyl-N,N-diisopropylamine; In tetrahydrofuran;

DOI:10.1002/hlca.19910740840

Reference yield:

N'-[9-((2R,4R,5R)-4-Hydroxy-5-hydroxymethyl-tetrahydro-furan-2-yl)-9H-purin-6-yl]-N,N-dimethyl-formamidine (17331-12-3,143771-69-1) → 9-<2'-deoxy-5'-O-(4,4'-dimethoxytrityl)-β-D-threo-pentofuranosyl>-N6-<(dimethylamino)methylidene>adenine 3'-<(2-cyanoethyl) N,N-diisopropylphosphoramidite> (139260-85-8,149572-85-0,149572-86-1)

Guidance literature:

Multi-step reaction with 2 steps

1: pyridine, (i-Pr)2EtN / 3.5 h / Ambient temperature

2: 96 percent / tetrahydrofuran / 0.5 h / Ambient temperature

With pyridine; N-ethyl-N,N-diisopropylamine; In tetrahydrofuran;

DOI:10.1002/hlca.19910740840

Reference yield:

9-(2'-deoxy-β-D-threo-ribofuranosyl)-adenine (13276-53-4,7005-15-4) → 9-<2'-deoxy-5'-O-(4,4'-dimethoxytrityl)-β-D-threo-pentofuranosyl>-N6-<(dimethylamino)methylidene>adenine 3'-<(2-cyanoethyl) N,N-diisopropylphosphoramidite> (139260-85-8,149572-85-0,149572-86-1)

Guidance literature:

Multi-step reaction with 3 steps

1: dimethylformamide / 18 h

2: pyridine, (i-Pr)2EtN / 3.5 h / Ambient temperature

3: 96 percent / tetrahydrofuran / 0.5 h / Ambient temperature

With pyridine; N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; N,N-dimethyl-formamide;

DOI:10.1002/hlca.19910740840

upstream raw materials:

4,4'-dimethoxytrityl chloride

N'-[9-((2R,4R,5R)-4-Hydroxy-5-hydroxymethyl-tetrahydro-furan-2-yl)-9H-purin-6-yl]-N,N-dimethyl-formamidine

9-(2'-deoxy-β-D-threo-ribofuranosyl)-adenine

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