{(S)-1-[Hydroxy-((R)-1-phenyl-ethylcarbamoyl)-methyl]-5-[(morpholine-4-carbonyl)-amino]-pentyl}-carbamic acid 1-(4-fluoro-benzyl)-cyclobutylmethyl ester

Base Information

• Chemical Name: {(S)-1-[Hydroxy-((R)-1-phenyl-ethylcarbamoyl)-methyl]-5-[(morpholine-4-carbonyl)-amino]-pentyl}-carbamic acid 1-(4-fluoro-benzyl)-cyclobutylmethyl ester
• CAS No.: 568591-22-0
• Molecular Formula: C₃₃H₄₅FN₄O₆
• Molecular Weight: 612.742

Synonyms:

Chemical Property of {(S)-1-[Hydroxy-((R)-1-phenyl-ethylcarbamoyl)-methyl]-5-[(morpholine-4-carbonyl)-amino]-pentyl}-carbamic acid 1-(4-fluoro-benzyl)-cyclobutylmethyl ester

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of {(S)-1-[Hydroxy-((R)-1-phenyl-ethylcarbamoyl)-methyl]-5-[(morpholine-4-carbonyl)-amino]-pentyl}-carbamic acid 1-(4-fluoro-benzyl)-cyclobutylmethyl ester

There total 9 articles about {(S)-1-[Hydroxy-((R)-1-phenyl-ethylcarbamoyl)-methyl]-5-[(morpholine-4-carbonyl)-amino]-pentyl}-carbamic acid 1-(4-fluoro-benzyl)-cyclobutylmethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

benzyl {(5S)-5-[(tert-butoxycarbonyl)amino]-6-oxohexyl}carbamate (82689-16-5) → {(S)-1-[Hydroxy-((R)-1-phenyl-ethylcarbamoyl)-methyl]-5-[(morpholine-4-carbonyl)-amino]-pentyl}-carbamic acid 1-(4-fluoro-benzyl)-cyclobutylmethyl ester (568591-22-0)

Guidance literature:

Multi-step reaction with 6 steps

1: CH₂Cl₂

2: aq. LiOH / dioxane / 100 °C

3: 99 percent / H₂ / Pd/C / ethanol / 2068.59 Torr

4: NEt₃ / tetrahydrofuran

5: 99 percent / HCl(g) / ethyl acetate / 0 °C

6: Et₃N / tetrahydrofuran

With hydrogenchloride; lithium hydroxide; hydrogen; triethylamine; palladium on activated charcoal; In tetrahydrofuran; 1,4-dioxane; ethanol; dichloromethane; ethyl acetate; 1: Passerini reaction;

DOI:10.1016/j.bmcl.2004.07.031

Reference yield:

(R)-(+)-α-methylbenzylisocyanide (17329-20-3,21872-32-2,21872-33-3,42412-74-8) → {(S)-1-[Hydroxy-((R)-1-phenyl-ethylcarbamoyl)-methyl]-5-[(morpholine-4-carbonyl)-amino]-pentyl}-carbamic acid 1-(4-fluoro-benzyl)-cyclobutylmethyl ester (568591-22-0)

Guidance literature:

Multi-step reaction with 6 steps

1: CH₂Cl₂

2: aq. LiOH / dioxane / 100 °C

3: 99 percent / H₂ / Pd/C / ethanol / 2068.59 Torr

4: NEt₃ / tetrahydrofuran

5: 99 percent / HCl(g) / ethyl acetate / 0 °C

6: Et₃N / tetrahydrofuran

With hydrogenchloride; lithium hydroxide; hydrogen; triethylamine; palladium on activated charcoal; In tetrahydrofuran; 1,4-dioxane; ethanol; dichloromethane; ethyl acetate; 1: Passerini reaction;

DOI:10.1016/j.bmcl.2004.07.031

Reference yield:

[(S)-5-tert-Butoxycarbonylamino-6-hydroxy-6-((R)-1-phenyl-ethylcarbamoyl)-hexyl]-carbamic acid benzyl ester (568591-15-1) → {(S)-1-[Hydroxy-((R)-1-phenyl-ethylcarbamoyl)-methyl]-5-[(morpholine-4-carbonyl)-amino]-pentyl}-carbamic acid 1-(4-fluoro-benzyl)-cyclobutylmethyl ester (568591-22-0)

Guidance literature:

Multi-step reaction with 4 steps

1: 99 percent / H₂ / Pd/C / ethanol / 2068.59 Torr

2: NEt₃ / tetrahydrofuran

3: 99 percent / HCl(g) / ethyl acetate / 0 °C

4: Et₃N / tetrahydrofuran

With hydrogenchloride; hydrogen; triethylamine; palladium on activated charcoal; In tetrahydrofuran; ethanol; ethyl acetate;

DOI:10.1016/j.bmcl.2004.07.031

upstream raw materials:

Morpholine-4-carboxylic acid [(S)-5-amino-6-hydroxy-6-((R)-1-phenyl-ethylcarbamoyl)-hexyl]-amide

ethyl cyclobutylcarboxylate

benzyl {(5S)-5-[(tert-butoxycarbonyl)amino]-6-oxohexyl}carbamate

(R)-(+)-α-methylbenzylisocyanide

Post a RFQ

Cas No.:

Product Name:

Quantity:

Please select Metric Ton KG G Pound L ML

Email:

Company name:

Valid Period:

Detailed Requirements:

• Sample
• MOQ
• GMP
• FDA
• Price
  FOB CIF CFR EXW
• Urgent purchase

Enter 15 to 2000 letters.Word count: 0 letters

Attach files(File Format: Jpeg, Jpg, Gif, Png, PDF, PPT, Zip, Rar,Word or Excel Maximum File Size: 3MB)

Remove

Submit

1

What can I do for you?
Get Best Price

Get Best Price for 568591-22-0 {(S)-1-[Hydroxy-((R)-1-phenyl-ethylcarbamoyl)-methyl]-5-[(morpholine-4-carbonyl)-amino]-pentyl}-carbamic acid 1-(4-fluoro-benzyl)-cyclobutylmethyl ester

Send

Send

Metric Ton KG G Pound L ML

Send

Send