[(3S)-4-[(2-{[(1,1-dimethylethyl)oxy]-carbonyl}-6-fluoro-2,3,4,5-tetrahydro-1H-2-benzazepin-7-yl)amino]-4-oxo-3-({[(phenylmethyl)oxy]carbonyl}amino)butyl](dimethyl)sulfonium iodide

Base Information

Chemical Name:[(3S)-4-[(2-{[(1,1-dimethylethyl)oxy]-carbonyl}-6-fluoro-2,3,4,5-tetrahydro-1H-2-benzazepin-7-yl)amino]-4-oxo-3-({[(phenylmethyl)oxy]carbonyl}amino)butyl](dimethyl)sulfonium iodide
CAS No.:939043-60-4
Molecular Formula:C₂₉H₃₉FN₃O₅S*I
Molecular Weight:687.615
Hs Code.:

[(3S)-4-[(2-{[(1,1-dimethylethyl)oxy]-carbonyl}-6-fluoro-2,3,4,5-tetrahydro-1H-2-benzazepin-7-yl)amino]-4-oxo-3-({[(phenylmethyl)oxy]carbonyl}amino)butyl](dimethyl)sulfonium iodide

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Chemical Property of [(3S)-4-[(2-{[(1,1-dimethylethyl)oxy]-carbonyl}-6-fluoro-2,3,4,5-tetrahydro-1H-2-benzazepin-7-yl)amino]-4-oxo-3-({[(phenylmethyl)oxy]carbonyl}amino)butyl](dimethyl)sulfonium iodide

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Technology Process of [(3S)-4-[(2-{[(1,1-dimethylethyl)oxy]-carbonyl}-6-fluoro-2,3,4,5-tetrahydro-1H-2-benzazepin-7-yl)amino]-4-oxo-3-({[(phenylmethyl)oxy]carbonyl}amino)butyl](dimethyl)sulfonium iodide

There total 11 articles about [(3S)-4-[(2-{[(1,1-dimethylethyl)oxy]-carbonyl}-6-fluoro-2,3,4,5-tetrahydro-1H-2-benzazepin-7-yl)amino]-4-oxo-3-({[(phenylmethyl)oxy]carbonyl}amino)butyl](dimethyl)sulfonium iodide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 939043-59-1
1,1-Dimethylethyl 6-fluoro-7-[(N-{[(phenylmethyl)oxy]carbonyl}-L-methionyl)amino]-1,3,4,5-tetrahydro-2H-2-benzazepine-2-carboxylate

: 939043-60-4
[(3S)-4-[(2-{[(1,1-dimethylethyl)oxy]-carbonyl}-6-fluoro-2,3,4,5-tetrahydro-1H-2-benzazepin-7-yl)amino]-4-oxo-3-({[(phenylmethyl)oxy]carbonyl}amino)butyl](dimethyl)sulfonium iodide

Guidance literature:: With methyl iodide; In acetonitrile; at 20 ℃;
DOI:10.1016/j.bmcl.2011.01.129

Reference yield:

: 939043-54-6
6-amino-5-fluoro-3,4-dihydronaphthalen-1(2H)-one

: 939043-60-4
[(3S)-4-[(2-{[(1,1-dimethylethyl)oxy]-carbonyl}-6-fluoro-2,3,4,5-tetrahydro-1H-2-benzazepin-7-yl)amino]-4-oxo-3-({[(phenylmethyl)oxy]carbonyl}amino)butyl](dimethyl)sulfonium iodide

Guidance literature:: Multi-step reaction with 5 steps

1.1: hydroxylamine hydrochloride; ammonium acetate / ethanol; water

1.2: PPA / 120 °C

2.1: borane / tetrahydrofuran / Heating

3.1: 20 °C

4.1: N-ethyl-N,N-diisopropylamine; HATU / dichloromethane / 20 °C

5.1: methyl iodide / acetonitrile / 20 °C

With borane; hydroxylamine hydrochloride; ammonium acetate; N-ethyl-N,N-diisopropylamine; HATU; methyl iodide; In tetrahydrofuran; ethanol; dichloromethane; water; acetonitrile;
DOI:10.1016/j.bmcl.2011.01.129

Reference yield:

: C₁₀H₁₀F₂O

: 939043-60-4
[(3S)-4-[(2-{[(1,1-dimethylethyl)oxy]-carbonyl}-6-fluoro-2,3,4,5-tetrahydro-1H-2-benzazepin-7-yl)amino]-4-oxo-3-({[(phenylmethyl)oxy]carbonyl}amino)butyl](dimethyl)sulfonium iodide

Guidance literature:: Multi-step reaction with 7 steps

1.1: methanesulfonic acid; phosphorus pentoxide / 20 °C

2.1: ammonia / methanol / 160 °C / Autoclave

3.1: hydroxylamine hydrochloride; ammonium acetate / ethanol; water

3.2: PPA / 120 °C

4.1: borane / tetrahydrofuran / Heating

5.1: 20 °C

6.1: N-ethyl-N,N-diisopropylamine; HATU / dichloromethane / 20 °C

7.1: methyl iodide / acetonitrile / 20 °C

With methanesulfonic acid; phosphorus pentoxide; borane; hydroxylamine hydrochloride; ammonium acetate; ammonia; N-ethyl-N,N-diisopropylamine; HATU; methyl iodide; In tetrahydrofuran; methanol; ethanol; dichloromethane; water; acetonitrile;
DOI:10.1016/j.bmcl.2011.01.129