N⁴-(6-amino-1-hexyl)-N⁴-(2',3'-O-isopropylidene-5'-adenosyl)-2(R,S),4-diaminobutanoic acid

Base Information

• Chemical Name: N⁴-(6-amino-1-hexyl)-N⁴-(2',3'-O-isopropylidene-5'-adenosyl)-2(R,S),4-diaminobutanoic acid
• CAS No.: 116701-43-0
• Molecular Formula: C₂₃H₃₈N₈O₅
• Molecular Weight: 506.605
• Mol file: 116701-43-0.mol

Synonyms:

Chemical Property of N⁴-(6-amino-1-hexyl)-N⁴-(2',3'-O-isopropylidene-5'-adenosyl)-2(R,S),4-diaminobutanoic acid

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of N⁴-(6-amino-1-hexyl)-N⁴-(2',3'-O-isopropylidene-5'-adenosyl)-2(R,S),4-diaminobutanoic acid

There total 1 articles about N⁴-(6-amino-1-hexyl)-N⁴-(2',3'-O-isopropylidene-5'-adenosyl)-2(R,S),4-diaminobutanoic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

5'-amino-5'-deoxy-2',3'-O-isopropylideneadenosine (21950-36-7) → N4-(6-amino-1-hexyl)-N4-(2',3'-O-isopropylidene-5'-adenosyl)-2(R,S),4-diaminobutanoic acid (116701-42-9,116701-43-0)

Guidance literature:

Multi-step reaction with 4 steps

1: 47.5 percent / N,N-diisopropylethylamine / acetonitrile / 18 h / 70 °C

2: 21.4 percent / N,N-diisopropylethylamine / acetonitrile / 72 h / 70 °C

3: Na₂CO₃ / methanol; H₂O / 6 h / 60 °C

4: H₂ / 10percent Pd/C / aq. formic acid / 5 h / 2172.02 Torr

With hydrogen; sodium carbonate; N-ethyl-N,N-diisopropylamine; palladium on activated charcoal; In methanol; formic acid; water; acetonitrile;

DOI:10.1021/jo00256a010

upstream raw materials:

5'-amino-5'-deoxy-2',3'-O-isopropylideneadenosine