C₄₅H₆₀O₅S₃Si

Base Information

• Chemical Name: C₄₅H₆₀O₅S₃Si
• CAS No.: 92714-68-6
• Molecular Formula: C₄₅H₆₀O₅S₃Si
• Molecular Weight: 805.252
• Mol file: 92714-68-6.mol

Synonyms:

Chemical Property of C₄₅H₆₀O₅S₃Si

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of C₄₅H₆₀O₅S₃Si

There total 22 articles about C₄₅H₆₀O₅S₃Si which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

(1S,2S,4aR,8aR)-2-Methyl-8-oxo-1,2,4a,5,8,8a-hexahydro-naphthalene-1-carboxylic acid methyl ester (92719-88-5) → C45H60O5S3Si (92714-68-6)

Guidance literature:

Multi-step reaction with 7 steps

1: 2.) NaOMe / 1.) diethylether, 0 deg C, 30 min. 2.) MeOH, 40 deg C, 24 h

2: TsOH / benzene / 72 h / 80 °C

3: LiAlH₄ / tetrahydrofuran / 2 h

4: Me₃SiCl, NaI / acetonitrile / 0.5 h

5: benzene / 5 h / 80 °C

6: BF₃*Et₂O / CH₂Cl₂ / 15 h

7: 1.) BuLi / 1.) THF, HMPA, 0 deg C, 30 min. 2.) THF, -78 to 25 deg C, 4 h

With n-butyllithium; chloro-trimethyl-silane; boron trifluoride diethyl etherate; sodium methylate; toluene-4-sulfonic acid; sodium iodide; lithium aluminium tetrahydride; In tetrahydrofuran; dichloromethane; acetonitrile; benzene;

DOI:10.1016/S0040-4039(01)91076-7

Reference yield:

(1S,2S,4aR,8aR)-2-Methyl-8-oxo-1,2,4a,5,8,8a-hexahydro-naphthalene-1-carboxylic acid methyl ester (92719-88-5) → C45H60O5S3Si (92714-68-6)

Guidance literature:

Multi-step reaction with 7 steps

1: 2.) NaOMe / 1.) diethylether, 0 deg C, 30 min. 2.) MeOH, 40 deg C, 24 h

2: TsOH / benzene / 72 h / 80 °C

3: LiAlH₄ / tetrahydrofuran / 2 h

4: Me₃SiCl, NaI / acetonitrile / 0.5 h

5: benzene / 5 h / 80 °C

6: BF₃*Et₂O / CH₂Cl₂ / 15 h

7: 1.) BuLi / 1.) THF, HMPA, 0 deg C, 30 min. 2.) THF, -78 to 25 deg C, 4 h

With n-butyllithium; chloro-trimethyl-silane; boron trifluoride diethyl etherate; sodium methylate; toluene-4-sulfonic acid; sodium iodide; lithium aluminium tetrahydride; In tetrahydrofuran; dichloromethane; acetonitrile; benzene;

DOI:10.1016/S0040-4039(01)91076-7

Reference yield:

(1R,2R,4aS,6R,8aR)-2,6-Dimethyl-8-oxo-1,2,4a,5,6,7,8,8a-octahydro-naphthalene-1-carboxylic acid methyl ester (92714-65-3) → C45H60O5S3Si (92714-68-6)

Guidance literature:

Multi-step reaction with 6 steps

1: TsOH / benzene / 72 h / 80 °C

2: LiAlH₄ / tetrahydrofuran / 2 h

3: Me₃SiCl, NaI / acetonitrile / 0.5 h

4: benzene / 5 h / 80 °C

5: BF₃*Et₂O / CH₂Cl₂ / 15 h

6: 1.) BuLi / 1.) THF, HMPA, 0 deg C, 30 min. 2.) THF, -78 to 25 deg C, 4 h

With n-butyllithium; chloro-trimethyl-silane; boron trifluoride diethyl etherate; toluene-4-sulfonic acid; sodium iodide; lithium aluminium tetrahydride; In tetrahydrofuran; dichloromethane; acetonitrile; benzene;

DOI:10.1016/S0040-4039(01)91076-7

upstream raw materials:

C₂₂H₃₀O₂S₃

tert-Butyl-((2S,4R,6R)-2-iodomethyl-6-methoxy-tetrahydro-pyran-4-yloxy)-diphenyl-silane

(1S,2S,4aR,8aR)-2-Methyl-8-oxo-1,2,4a,5,8,8a-hexahydro-naphthalene-1-carboxylic acid methyl ester

C₁₅H₂₄O₃