(alphaR)-alpha-Amino-3,5-dimethoxybenzeneacetic acid

Base Information

Chemical Name:(alphaR)-alpha-Amino-3,5-dimethoxybenzeneacetic acid
CAS No.:103889-85-6
Molecular Formula:C₁₀H₁₃NO₄
Molecular Weight:211.218
Hs Code.:
DSSTox Substance ID:DTXSID901238528
Nikkaji Number:J1.504.345H

Synonyms:103889-85-6;DTXSID901238528;AKOS015911245;(R)-2-Amino-2-(3,5-dimethoxyphenyl)acetic acid;(alphaR)-alpha-Amino-3,5-dimethoxybenzeneacetic acid;Benzeneacetic acid, alpha-amino-3,5-dimethoxy-, (R)-

Suppliers and Price of (alphaR)-alpha-Amino-3,5-dimethoxybenzeneacetic acid

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (alphaR)-alpha-Amino-3,5-dimethoxybenzeneacetic acid

Chemical Property:

XLogP3:-1.8
Hydrogen Bond Donor Count:2
Hydrogen Bond Acceptor Count:5
Rotatable Bond Count:4
Exact Mass:211.08445790
Heavy Atom Count:15
Complexity:210

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Canonical SMILES:COC1=CC(=CC(=C1)C(C(=O)O)N)OC
Isomeric SMILES:COC1=CC(=CC(=C1)[C@H](C(=O)O)N)OC

Technology Process of (alphaR)-alpha-Amino-3,5-dimethoxybenzeneacetic acid

There total 6 articles about (alphaR)-alpha-Amino-3,5-dimethoxybenzeneacetic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 135387-93-8
(S)-3-[(S)-2-Azido-2-(3,5-dimethoxy-phenyl)-acetyl]-4-benzyl-oxazolidin-2-one

: 103889-87-8
(S)-3,5-dimethoxyphenylglycine

: 103889-85-6
(R)-3,5-dimethoxyphenylglycine

Guidance literature:: Multistep reaction. Title compound not separated from byproducts; 1) hydrogenation, 2) acid hydrolysis;
DOI:10.1016/S0040-4039(00)78813-7

Reference yield:

: 4724-10-1
methyl 2-(3,5-dihydroxyphenyl)acetate

: 103889-85-6
(R)-3,5-dimethoxyphenylglycine

Guidance literature:: Multi-step reaction with 5 steps

2: base hydrolysis

4: 1) potassium hexamethyldisilzide, 2) trisyl azide

5: 1) hydrogenation, 2) acid hydrolysis

With 2,4,6-Triisopropylbenzenesulfonyl azide; potassium hexamethylsilazane;
DOI:10.1016/S0040-4039(00)78813-7

Reference yield:

: 4670-09-1
2-(3,5-dihydroxyphenyl)acetic acid

: 103889-85-6
(R)-3,5-dimethoxyphenylglycine

Guidance literature:: Multi-step reaction with 6 steps

1: 1) SOCl₂

3: base hydrolysis

5: 1) potassium hexamethyldisilzide, 2) trisyl azide

6: 1) hydrogenation, 2) acid hydrolysis

With thionyl chloride; 2,4,6-Triisopropylbenzenesulfonyl azide; potassium hexamethylsilazane;
DOI:10.1016/S0040-4039(00)78813-7