tert-butyl (2S,3R)-2-(3-methoxyphenyl)-6-methyl-3-nitro-3,4-dihydropyridine-1(2H)-carboxylate

Base Information

Chemical Name:tert-butyl (2S,3R)-2-(3-methoxyphenyl)-6-methyl-3-nitro-3,4-dihydropyridine-1(2H)-carboxylate
CAS No.:1402850-88-7
Molecular Formula:C₁₈H₂₄N₂O₅
Molecular Weight:348.399
Hs Code.:

Synonyms:

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Chemical Property of tert-butyl (2S,3R)-2-(3-methoxyphenyl)-6-methyl-3-nitro-3,4-dihydropyridine-1(2H)-carboxylate

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Technology Process of tert-butyl (2S,3R)-2-(3-methoxyphenyl)-6-methyl-3-nitro-3,4-dihydropyridine-1(2H)-carboxylate

There total 6 articles about tert-butyl (2S,3R)-2-(3-methoxyphenyl)-6-methyl-3-nitro-3,4-dihydropyridine-1(2H)-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 54.0%

: 877031-91-9
tert-butyl 3-methoxybenzylidenecarbamate

: 1402850-61-6
5-nitropent-1-yne

: 1402850-88-7
tert-butyl (2S,3R)-2-(3-methoxyphenyl)-6-methyl-3-nitro-3,4-dihydropyridine-1(2H)-carboxylate

: tert-butyl 2-(3-methoxyphenyl)-6-methyl-3-nitro-3,4-dihydropyridine-1(2H)-carboxylate

Guidance literature:: tert-butyl 3-methoxybenzylidenecarbamate; 5-nitropent-1-yne; With C₁₇H₂₁F₆N₃O; In toluene; at -15 ℃; for 24h; Inert atmosphere; Sealed tube;

With diphenyl hydrogen phosphate; In toluene; at 20 ℃; for 0.5h; Inert atmosphere;

With Echavarren's catalyst; In toluene; at 60 ℃; for 6h; diastereoselective reaction; Inert atmosphere;
DOI:10.1021/ol302459c

Reference yield:

: 591-31-1
3-methoxy-benzaldehyde

: 1402850-88-7
tert-butyl (2S,3R)-2-(3-methoxyphenyl)-6-methyl-3-nitro-3,4-dihydropyridine-1(2H)-carboxylate

: tert-butyl 2-(3-methoxyphenyl)-6-methyl-3-nitro-3,4-dihydropyridine-1(2H)-carboxylate

Guidance literature:: Multi-step reaction with 3 steps

1.1: formic acid / water / Inert atmosphere

2.1: potassium carbonate / tetrahydrofuran / Inert atmosphere

3.1: C₁₇H₂₁F₆N₃O / toluene / 24 h / -15 °C / Inert atmosphere; Sealed tube

3.2: 0.5 h / 20 °C / Inert atmosphere

3.3: 6 h / 60 °C / Inert atmosphere

With formic acid; C₁₇H₂₁F₆N₃O; potassium carbonate; In tetrahydrofuran; water; toluene;
DOI:10.1021/ol302459c

Reference yield:

: 774225-27-3
N-(tert-butoxycarbonyl)-α-(phenylsulfonyl)-3-methoxybenzylamine

: 1402850-88-7
tert-butyl (2S,3R)-2-(3-methoxyphenyl)-6-methyl-3-nitro-3,4-dihydropyridine-1(2H)-carboxylate

: tert-butyl 2-(3-methoxyphenyl)-6-methyl-3-nitro-3,4-dihydropyridine-1(2H)-carboxylate

Guidance literature:: Multi-step reaction with 2 steps

1.1: potassium carbonate / tetrahydrofuran / Inert atmosphere

2.1: C₁₇H₂₁F₆N₃O / toluene / 24 h / -15 °C / Inert atmosphere; Sealed tube

2.2: 0.5 h / 20 °C / Inert atmosphere

2.3: 6 h / 60 °C / Inert atmosphere

With C₁₇H₂₁F₆N₃O; potassium carbonate; In tetrahydrofuran; toluene;
DOI:10.1021/ol302459c