24,24-difluoro-5α,8α-(3,5-dioxo-4-phenyl-1,2,4-triazolidine-1,2-diyl)cholest-6-ene-1α,3β-diol

Base Information

Chemical Name:24,24-difluoro-5α,8α-(3,5-dioxo-4-phenyl-1,2,4-triazolidine-1,2-diyl)cholest-6-ene-1α,3β-diol
CAS No.:174201-38-8
Molecular Formula:C₃₅H₄₇F₂N₃O₄
Molecular Weight:611.773
Hs Code.:

Synonyms:

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Chemical Property of 24,24-difluoro-5α,8α-(3,5-dioxo-4-phenyl-1,2,4-triazolidine-1,2-diyl)cholest-6-ene-1α,3β-diol

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Technology Process of 24,24-difluoro-5α,8α-(3,5-dioxo-4-phenyl-1,2,4-triazolidine-1,2-diyl)cholest-6-ene-1α,3β-diol

There total 9 articles about 24,24-difluoro-5α,8α-(3,5-dioxo-4-phenyl-1,2,4-triazolidine-1,2-diyl)cholest-6-ene-1α,3β-diol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 174201-43-5
C₄₇H₇₅F₂N₃O₄Si₂

: 174201-38-8
24,24-difluoro-5α,8α-(3,5-dioxo-4-phenyl-1,2,4-triazolidine-1,2-diyl)cholest-6-ene-1α,3β-diol

Guidance literature:: With camphor-10-sulfonic acid; In methanol; chloroform; Yield given; Ambient temperature;
DOI:10.1248/cpb.44.62

Reference yield:

: 15988-11-1
4-Phenylurazole

: 174201-38-8
24,24-difluoro-5α,8α-(3,5-dioxo-4-phenyl-1,2,4-triazolidine-1,2-diyl)cholest-6-ene-1α,3β-diol

Guidance literature:: Multi-step reaction with 9 steps

1: ethyl acetate

2: 93 percent / DMAP / CH₂Cl₂ / Ambient temperature

3: 86 percent / dimethylsulfoxide / 2 h / 65 °C

4: 90 percent / diisobutylaluminum hydride / toluene; CH₂Cl₂ / 0.42 h / 0 °C

5: 1.) Zn / 1.) THF, reflux, 10 min, 2.) THF, reflux, 10 min

6: 67 percent / diethyl ether / a) 0 deg C, 30 min, b) RT, 2 h

7: DMAP / CH₂Cl₂ / 0.5 h / Ambient temperature

8: Bu₃SnH, 2,2'-azobisisobutyronitrile / toluene / 0.5 h / Heating

9: camphorsulfonic acid / methanol; CHCl₃ / Ambient temperature

With dmap; 2,2'-azobis(isobutyronitrile); camphor-10-sulfonic acid; tri-n-butyl-tin hydride; diisobutylaluminium hydride; zinc; In methanol; diethyl ether; dichloromethane; chloroform; dimethyl sulfoxide; ethyl acetate; toluene;
DOI:10.1248/cpb.44.62

Reference yield:

: 126771-88-8
1α,3β-bis<(tert-butyldimethylsilyl)oxy>-23,24-bisnorchol-5,7-dien-22-ol

: 174201-38-8
24,24-difluoro-5α,8α-(3,5-dioxo-4-phenyl-1,2,4-triazolidine-1,2-diyl)cholest-6-ene-1α,3β-diol

Guidance literature:: Multi-step reaction with 9 steps

1: ethyl acetate

2: 93 percent / DMAP / CH₂Cl₂ / Ambient temperature

3: 86 percent / dimethylsulfoxide / 2 h / 65 °C

4: 90 percent / diisobutylaluminum hydride / toluene; CH₂Cl₂ / 0.42 h / 0 °C

5: 1.) Zn / 1.) THF, reflux, 10 min, 2.) THF, reflux, 10 min

6: 67 percent / diethyl ether / a) 0 deg C, 30 min, b) RT, 2 h

7: DMAP / CH₂Cl₂ / 0.5 h / Ambient temperature

8: Bu₃SnH, 2,2'-azobisisobutyronitrile / toluene / 0.5 h / Heating

9: camphorsulfonic acid / methanol; CHCl₃ / Ambient temperature

With dmap; 2,2'-azobis(isobutyronitrile); camphor-10-sulfonic acid; tri-n-butyl-tin hydride; diisobutylaluminium hydride; zinc; In methanol; diethyl ether; dichloromethane; chloroform; dimethyl sulfoxide; ethyl acetate; toluene;
DOI:10.1248/cpb.44.62