Boc-ΔLyz(Cbz)-OMe

Base Information

• Chemical Name: Boc-ΔLyz(Cbz)-OMe
• CAS No.: 114684-77-4
• Molecular Formula: C₂₀H₂₈N₂O₆
• Molecular Weight: 392.452
• Mol file: 114684-77-4.mol

Synonyms:

Chemical Property of Boc-ΔLyz(Cbz)-OMe

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of Boc-ΔLyz(Cbz)-OMe

There total 5 articles about Boc-ΔLyz(Cbz)-OMe which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

benzyl 4-hydroxybutylcarbamate (17996-13-3) → Boc-ΔLyz(Cbz)-OMe (114684-77-4)

Guidance literature:

Multi-step reaction with 5 steps

1: 84 percent / (COCl)2 / dimethylsulfoxide / 1 h / further oxidizing agents

2: 85 percent / t-BuOK / CH₂Cl₂ / -60 deg C 1 h and room temp 3 h

3: 85 percent / 1 M LiOH / 3 h / Ambient temperature

4: 85 percent / SOCl₂ / diethyl ether

5: 2.) N-methylmorpholin

With 4-methyl-morpholine; lithium hydroxide; thionyl chloride; oxalyl dichloride; potassium tert-butylate; In diethyl ether; dichloromethane; dimethyl sulfoxide;

DOI:10.1016/S0040-4039(00)96397-4

Reference yield:

4-benzyloxycarbonylaminobutyric acid methyl ester (67706-63-2) → Boc-ΔLyz(Cbz)-OMe (114684-77-4)

Guidance literature:

Multi-step reaction with 6 steps

1: NaBH₄ / LiAlH₄

2: 84 percent / (COCl)2 / dimethylsulfoxide / 1 h / further oxidizing agents

3: 85 percent / t-BuOK / CH₂Cl₂ / -60 deg C 1 h and room temp 3 h

4: 85 percent / 1 M LiOH / 3 h / Ambient temperature

5: 85 percent / SOCl₂ / diethyl ether

6: 2.) N-methylmorpholin

With 4-methyl-morpholine; lithium hydroxide; sodium tetrahydroborate; thionyl chloride; oxalyl dichloride; potassium tert-butylate; In diethyl ether; dichloromethane; dimethyl sulfoxide;

DOI:10.1016/S0040-4039(00)96397-4

Reference yield:

4-[(benzyloxycarbonyl)amino]butyric aldehyde (69037-98-5) → Boc-ΔLyz(Cbz)-OMe (114684-77-4)

Guidance literature:

Multi-step reaction with 4 steps

1: 85 percent / t-BuOK / CH₂Cl₂ / -60 deg C 1 h and room temp 3 h

2: 85 percent / 1 M LiOH / 3 h / Ambient temperature

3: 85 percent / SOCl₂ / diethyl ether

4: 2.) N-methylmorpholin

With 4-methyl-morpholine; lithium hydroxide; thionyl chloride; potassium tert-butylate; In diethyl ether; dichloromethane;

DOI:10.1016/S0040-4039(00)96397-4

upstream raw materials:

benzyl 4-hydroxybutylcarbamate

4-benzyloxycarbonylaminobutyric acid methyl ester

4-[(benzyloxycarbonyl)amino]butyric aldehyde

Cbz-δLyz(Cbz)-OH