Technology Process of (1S,9R)-10,12-Bis-(4-methoxy-benzyl)-3,3-dimethyl-2,4,8-trioxa-10,12-diaza-tricyclo[7.2.2.01,5]tridecane-11,13-dione
There total 6 articles about (1S,9R)-10,12-Bis-(4-methoxy-benzyl)-3,3-dimethyl-2,4,8-trioxa-10,12-diaza-tricyclo[7.2.2.01,5]tridecane-11,13-dione which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
With
N-Bromosuccinimide; 4 A molecular sieve; barium carbonate;
In
chloroform;
for 72h;
Ambient temperature;
DOI:10.1246/cl.1984.1547
- Guidance literature:
-
Multi-step reaction with 6 steps
1: 56 percent / NaClO3, OsO4, H2O / dioxane / 72 h / Ambient temperature
2: 95 percent / pirydinium p-toluenesulfonate / acetone / 72 h / Ambient temperature
3: NH2NH2*H2O / dimethylformamide / 3 h / 0 °C
4: 62 percent / NaH / dimethylformamide / 12 h / Ambient temperature
5: hydrogen / 10percent Pd/C / methanol / 24 h
6: 86 percent / NBS, BaCO3, mol. sieves 4A / CHCl3 / 72 h / Ambient temperature
With
sodium chlorate; N-Bromosuccinimide; osmium(VIII) oxide; 4 A molecular sieve; water; hydrogen; sodium hydride; hydrazine hydrate; barium carbonate;
palladium on activated charcoal; pyridinium p-toluenesulfonate;
In
1,4-dioxane; methanol; chloroform; N,N-dimethyl-formamide; acetone;
DOI:10.1246/cl.1984.1547
- Guidance literature:
-
Multi-step reaction with 5 steps
1: 95 percent / pirydinium p-toluenesulfonate / acetone / 72 h / Ambient temperature
2: NH2NH2*H2O / dimethylformamide / 3 h / 0 °C
3: 62 percent / NaH / dimethylformamide / 12 h / Ambient temperature
4: hydrogen / 10percent Pd/C / methanol / 24 h
5: 86 percent / NBS, BaCO3, mol. sieves 4A / CHCl3 / 72 h / Ambient temperature
With
N-Bromosuccinimide; 4 A molecular sieve; hydrogen; sodium hydride; hydrazine hydrate; barium carbonate;
palladium on activated charcoal; pyridinium p-toluenesulfonate;
In
methanol; chloroform; N,N-dimethyl-formamide; acetone;
DOI:10.1246/cl.1984.1547
![4-(2-Hydroxy-ethyl)-6,9-bis-(4-methoxy-benzyl)-2,2-dimethyl-1,3-dioxa-6,9-diaza-spiro[4.5]decane-7,10-dione](/Databaselist/images/loading.webp)
