Technology Process of methyl (E)-2,2,3-triphenyl-3-hexenedioate
There total 5 articles about methyl (E)-2,2,3-triphenyl-3-hexenedioate which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
Multi-step reaction with 6 steps
1: 1.) butyllithium / 1.) THF, hexan, 16 h, 0 deg C, 2.) -30 deg C, then 1 h, 25 deg C
2: potassium trt-butoxide, butillithium / tetrahydrofuran; hexane / 2 h, -50 deg C, then 12 h, 0 deg C
3: 71 percent / O3 / CH2Cl2 / 1 h / -75 °C
4: 1.) potassium tert-butoxide / 1.) THF, 30 min, 25 deg C, 2.) -75 deg C, THF, then 1 h, -25 deg C
5: 90 percent / MgBr2 / diethyl ether
6: methanol; diethyl ether
With
n-butyllithium; potassium tert-butylate; ozone; magnesium bromide;
In
tetrahydrofuran; methanol; diethyl ether; hexane; dichloromethane;
DOI:10.1016/S0040-4020(01)85984-6
- Guidance literature:
-
Multi-step reaction with 5 steps
1: potassium trt-butoxide, butillithium / tetrahydrofuran; hexane / 2 h, -50 deg C, then 12 h, 0 deg C
2: 71 percent / O3 / CH2Cl2 / 1 h / -75 °C
3: 1.) potassium tert-butoxide / 1.) THF, 30 min, 25 deg C, 2.) -75 deg C, THF, then 1 h, -25 deg C
4: 90 percent / MgBr2 / diethyl ether
5: methanol; diethyl ether
With
n-butyllithium; potassium tert-butylate; ozone; magnesium bromide;
In
tetrahydrofuran; methanol; diethyl ether; hexane; dichloromethane;
DOI:10.1016/S0040-4020(01)85984-6
- Guidance literature:
-
Multi-step reaction with 3 steps
1: 1.) potassium tert-butoxide / 1.) THF, 30 min, 25 deg C, 2.) -75 deg C, THF, then 1 h, -25 deg C
2: 90 percent / MgBr2 / diethyl ether
3: methanol; diethyl ether
With
potassium tert-butylate; magnesium bromide;
In
methanol; diethyl ether;
DOI:10.1016/S0040-4020(01)85984-6
