(2S,3S)-3-[(E)-(S)-4-(Benzyloxycarbonyl-methyl-amino)-5-phenyl-pent-2-enoyloxy]-2-methyl-decanoic acid (S)-1-benzyloxycarbonyl-2-methyl-propyl ester

Base Information

Chemical Name:(2S,3S)-3-[(E)-(S)-4-(Benzyloxycarbonyl-methyl-amino)-5-phenyl-pent-2-enoyloxy]-2-methyl-decanoic acid (S)-1-benzyloxycarbonyl-2-methyl-propyl ester
CAS No.:182621-46-1
Molecular Formula:C₄₃H₅₅NO₈
Molecular Weight:713.912
Hs Code.:

(2S,3S)-3-[(E)-(S)-4-(Benzyloxycarbonyl-methyl-amino)-5-phenyl-pent-2-enoyloxy]-2-methyl-decanoic acid (S)-1-benzyloxycarbonyl-2-methyl-propyl ester

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Chemical Property of (2S,3S)-3-[(E)-(S)-4-(Benzyloxycarbonyl-methyl-amino)-5-phenyl-pent-2-enoyloxy]-2-methyl-decanoic acid (S)-1-benzyloxycarbonyl-2-methyl-propyl ester

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Technology Process of (2S,3S)-3-[(E)-(S)-4-(Benzyloxycarbonyl-methyl-amino)-5-phenyl-pent-2-enoyloxy]-2-methyl-decanoic acid (S)-1-benzyloxycarbonyl-2-methyl-propyl ester

There total 5 articles about (2S,3S)-3-[(E)-(S)-4-(Benzyloxycarbonyl-methyl-amino)-5-phenyl-pent-2-enoyloxy]-2-methyl-decanoic acid (S)-1-benzyloxycarbonyl-2-methyl-propyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 124-13-0
Octanal

: 182621-46-1
(2S,3S)-3-[(E)-(S)-4-(Benzyloxycarbonyl-methyl-amino)-5-phenyl-pent-2-enoyloxy]-2-methyl-decanoic acid (S)-1-benzyloxycarbonyl-2-methyl-propyl ester

Guidance literature:: Multi-step reaction with 6 steps

1: 74 percent / Bu₂BOTf, Et₃N

2: 97 percent / 2,6-lutidine

3: 97 percent / LiOH, H₂O₂

4: 1.) 2,4,6-Cl₃-C₆H₂COCl, Et₃N

5: 90 percent / HF / acetonitrile

With 2,6-dimethylpyridine; lithium hydroxide; di-n-butylboryl trifluoromethanesulfonate; 2,4,6-trichlorobenzoyl chloride; hydrogen fluoride; dihydrogen peroxide; triethylamine; In acetonitrile;
DOI:10.1016/0040-4039(96)01415-3

Reference yield:

: 182621-38-1
(2S,3R)-3-(tert-butyldimethylsilyloxy)-2-methyl-decanoic acid

: 182621-46-1
(2S,3S)-3-[(E)-(S)-4-(Benzyloxycarbonyl-methyl-amino)-5-phenyl-pent-2-enoyloxy]-2-methyl-decanoic acid (S)-1-benzyloxycarbonyl-2-methyl-propyl ester

Guidance literature:: Multi-step reaction with 3 steps

1: 1.) 2,4,6-Cl₃-C₆H₂COCl, Et₃N

2: 90 percent / HF / acetonitrile

With 2,4,6-trichlorobenzoyl chloride; hydrogen fluoride; triethylamine; In acetonitrile;
DOI:10.1016/0040-4039(96)01415-3

Reference yield:

: 182621-36-9
(4S)-3<(2'S,3'R)-2'-methyl-3'-hydroxydecanoyl>-4-phenylmethyl-2-oxazolidinone

: 182621-46-1
(2S,3S)-3-[(E)-(S)-4-(Benzyloxycarbonyl-methyl-amino)-5-phenyl-pent-2-enoyloxy]-2-methyl-decanoic acid (S)-1-benzyloxycarbonyl-2-methyl-propyl ester

Guidance literature:: Multi-step reaction with 5 steps

1: 97 percent / 2,6-lutidine

2: 97 percent / LiOH, H₂O₂

3: 1.) 2,4,6-Cl₃-C₆H₂COCl, Et₃N

4: 90 percent / HF / acetonitrile

With 2,6-dimethylpyridine; lithium hydroxide; 2,4,6-trichlorobenzoyl chloride; hydrogen fluoride; dihydrogen peroxide; triethylamine; In acetonitrile;
DOI:10.1016/0040-4039(96)01415-3