(2R,3S)-2-methylpentane-1,3-diol

Base Information

Chemical Name:(2R,3S)-2-methylpentane-1,3-diol
CAS No.:208766-56-7
Molecular Formula:C₆H₁₄O₂
Molecular Weight:118.176
Hs Code.:
UNII:TVG883H3Z6,489NK7IHFD
Nikkaji Number:J1.184.351D

Synonyms:(2R,3S)-2-methylpentane-1,3-diol;(2R,3S)-2-Methyl-1,3-pentanediol;TVG883H3Z6;2-Methyl-1,3-pentanediol, (R,S)-;489NK7IHFD;UNII-TVG883H3Z6;2-Methyl-1,3-pentanediol, (2R,3S)-;1,3-Pentanediol, 2-methyl-, (2R,3S)-;2-Methyl-1,3-pentanediol, (R,S)-(-)-;208766-56-7;2-Methyl-1,3-pentanediol, (R*,S*)-;1,3-Pentanediol, 2-methyl-, (R*,S*)-;2-Methyl-1,3-pentanediol, (R,S)-(+/-)-;1,3-Pentanediol, 2-methyl-, (2R,3S)-rel-;121054-26-0;UNII-489NK7IHFD

Suppliers and Price of (2R,3S)-2-methylpentane-1,3-diol

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

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Chemical Property of (2R,3S)-2-methylpentane-1,3-diol

Chemical Property:

XLogP3:0.6
Hydrogen Bond Donor Count:2
Hydrogen Bond Acceptor Count:2
Rotatable Bond Count:3
Exact Mass:118.099379685
Heavy Atom Count:8
Complexity:54.5

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Canonical SMILES:CCC(C(C)CO)O
Isomeric SMILES:CC[C@@H]([C@H](C)CO)O

Technology Process of (2R,3S)-2-methylpentane-1,3-diol

There total 1 articles about (2R,3S)-2-methylpentane-1,3-diol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 123-38-6
propionaldehyde

: 94339-79-4
(2S,3R)-2-methylpentane-1,3-diol

: 261614-97-5
(2R,3R)-2-methylpentane-1,3-diol

: 149-31-5,94339-79-4,103729-83-5,103729-87-9,121054-24-8,121054-26-0,94953-91-0
(2S,3S)-2-methylpentane-1,3-diol

: 208766-56-7
(2R,3S)-2-methylpentane-1,3-diol

Guidance literature:: propionaldehyde; With water; at 20 ℃; for 3h;

With sodium tetrahydroborate; In methanol; at 0 ℃; for 1h; Further stages. Title compound not separated from byproducts.;
DOI:10.1039/b702559a

Reference yield:

: 208766-56-7
(2R,3S)-2-methylpentane-1,3-diol

: C₁₉H₂₈Cl₂O₄Si

Guidance literature:: Multi-step reaction with 5 steps

1: 91 percent / pyridine / CH₂Cl₂ / 3.5 h / 0 °C

2: imidazole / dimethylformamide / 14 h / Ambient temperature

3: 80 percent / KOH / methanol / 5 h / Heating

4: 84 percent / RuCl₃, NaIO₄ / CCl₄; acetonitrile; H₂O / 10 h / Ambient temperature; phosphate buffer pH 7

5: Et₃N / tetrahydrofuran / 11 h / Ambient temperature

With pyridine; 1H-imidazole; ruthenium trichloride; potassium hydroxide; sodium periodate; triethylamine; In tetrahydrofuran; methanol; tetrachloromethane; dichloromethane; water; N,N-dimethyl-formamide; acetonitrile;
DOI:10.1002/(SICI)1099-0690(199806)1998:6<1135::AID-EJOC1135>3.0.CO;2-K

Reference yield:

: 208766-56-7
(2R,3S)-2-methylpentane-1,3-diol

: 69769-68-2,72592-59-7,72592-60-0,72984-64-6,74080-52-7,74080-53-8,74080-54-9,74111-24-3,78853-35-7,78853-36-8,79703-07-4,79703-08-5,110996-50-4,112571-15-0
(2S,3R)-2,3-dihydro-6-[(1'R)-1'-methyl-2'-oxobutyl]-2,3,5-trimethyl-4H-pyran-4-one

Guidance literature:: Multi-step reaction with 9 steps

1: 91 percent / pyridine / CH₂Cl₂ / 3.5 h / 0 °C

2: imidazole / dimethylformamide / 14 h / Ambient temperature

3: 80 percent / KOH / methanol / 5 h / Heating

4: 84 percent / RuCl₃, NaIO₄ / CCl₄; acetonitrile; H₂O / 10 h / Ambient temperature; phosphate buffer pH 7

5: Et₃N / tetrahydrofuran / 11 h / Ambient temperature

6: DMAP / benzene / 3 h / 0 °C

7: 66 percent / TiCl₄, EtN(iPr)2 / CH₂Cl₂ / -78 deg C, 3 h; -10 deg C, 2 h; -10 to -20 deg C, 2 d

8: 47 percent / 46percent HF / acetonitrile / 14 h / 0 - 4 °C

9: Dess-Martin periodinane, pyridine / CH₂Cl₂ / 0.42 h

With pyridine; 1H-imidazole; dmap; ruthenium trichloride; potassium hydroxide; sodium periodate; hydrogen fluoride; titanium tetrachloride; Dess-Martin periodane; triethylamine; N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; methanol; tetrachloromethane; dichloromethane; water; N,N-dimethyl-formamide; acetonitrile; benzene;
DOI:10.1002/(SICI)1099-0690(199806)1998:6<1135::AID-EJOC1135>3.0.CO;2-K