Technology Process of 2-<4-<2-(2-Propenyl)phenyl>buta-1,3-diynyl>-α-diazoacetophenone
There total 7 articles about 2-<4-<2-(2-Propenyl)phenyl>buta-1,3-diynyl>-α-diazoacetophenone which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
Multi-step reaction with 7 steps
1: 89 percent / Et3N
2: tetr-butyllithium / diethyl ether / 1.) -78 deg C, 20 min, 2.) 25 deg C, 12 h
3: 78 percent / tetrabutylammonium fluoride / tetrahydrofuran; H2O / 0 °C
4: 47 percent / CBr4, triphenylphosphine / CH2Cl2 / 0.33 h / Ambient temperature
5: 42 percent / hydroxylamine hydrochloride, CuCl2, n-butylamine / ethanol / 1 h / Ambient temperature
6: 1.) potassium trimethylsilanolate, 2.) methylchloroformate / 1.) ether, 5 h, 2.) ether, 25 deg C, 4 h
7: diethyl ether / 16 h
With
carbon tetrabromide; hydroxylamine hydrochloride; potassium trimethylsilonate; tetrabutyl ammonium fluoride; tert.-butyl lithium; N-butylamine; triethylamine; methyl chloroformate; triphenylphosphine; copper dichloride;
In
tetrahydrofuran; diethyl ether; ethanol; dichloromethane; water;
DOI:10.1021/jo00075a045
- Guidance literature:
-
Multi-step reaction with 3 steps
1: 42 percent / hydroxylamine hydrochloride, CuCl2, n-butylamine / ethanol / 1 h / Ambient temperature
2: 1.) potassium trimethylsilanolate, 2.) methylchloroformate / 1.) ether, 5 h, 2.) ether, 25 deg C, 4 h
3: diethyl ether / 16 h
With
hydroxylamine hydrochloride; potassium trimethylsilonate; N-butylamine; methyl chloroformate; copper dichloride;
In
diethyl ether; ethanol;
DOI:10.1021/jo00075a045
- Guidance literature:
-
Multi-step reaction with 6 steps
1: tetr-butyllithium / diethyl ether / 1.) -78 deg C, 20 min, 2.) 25 deg C, 12 h
2: 78 percent / tetrabutylammonium fluoride / tetrahydrofuran; H2O / 0 °C
3: 47 percent / CBr4, triphenylphosphine / CH2Cl2 / 0.33 h / Ambient temperature
4: 42 percent / hydroxylamine hydrochloride, CuCl2, n-butylamine / ethanol / 1 h / Ambient temperature
5: 1.) potassium trimethylsilanolate, 2.) methylchloroformate / 1.) ether, 5 h, 2.) ether, 25 deg C, 4 h
6: diethyl ether / 16 h
With
carbon tetrabromide; hydroxylamine hydrochloride; potassium trimethylsilonate; tetrabutyl ammonium fluoride; tert.-butyl lithium; N-butylamine; methyl chloroformate; triphenylphosphine; copper dichloride;
In
tetrahydrofuran; diethyl ether; ethanol; dichloromethane; water;
DOI:10.1021/jo00075a045
