2-Pyrimidinecarboxylic acid, 5-phenyl-, 4-[[4-(pentyloxy)phenoxy]carbonyl]phenyl ester

Base Information

• Chemical Name: 2-Pyrimidinecarboxylic acid, 5-phenyl-, 4-[[4-(pentyloxy)phenoxy]carbonyl]phenyl ester
• CAS No.: 106307-69-1
• Molecular Formula: C₂₉H₂₆N₂O₅
• Molecular Weight: 482.536
• Mol file: 106307-69-1.mol

Synonyms:

Chemical Property of 2-Pyrimidinecarboxylic acid, 5-phenyl-, 4-[[4-(pentyloxy)phenoxy]carbonyl]phenyl ester

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 2-Pyrimidinecarboxylic acid, 5-phenyl-, 4-[[4-(pentyloxy)phenoxy]carbonyl]phenyl ester

There total 5 articles about 2-Pyrimidinecarboxylic acid, 5-phenyl-, 4-[[4-(pentyloxy)phenoxy]carbonyl]phenyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

2-methyl-5-phenylpyrimidine (34771-47-6) → p-Amyloxyphenyl p-(5-Phenyl-2-pyrimidylcarbonyloxy)benzoate (106307-69-1)

Guidance literature:

Multi-step reaction with 2 steps

1: 61 percent / selenium dioxide / pyridine / 4 h / Heating

2: 37 percent / triphenylphosphine, carbon tetrachloride, triethylamine / 10 h / Ambient temperature

With tetrachloromethane; selenium(IV) oxide; triethylamine; triphenylphosphine; In pyridine;

DOI:10.1007/BF00515002

Reference yield:

2-Tribromomethyl-5-phenylpyrimidine (106307-59-9) → p-Amyloxyphenyl p-(5-Phenyl-2-pyrimidylcarbonyloxy)benzoate (106307-69-1)

Guidance literature:

Multi-step reaction with 2 steps

1: 56 percent / 2N aq. silver nitrate / acetic acid / 1.5 h / Heating

2: 37 percent / triphenylphosphine, carbon tetrachloride, triethylamine / 10 h / Ambient temperature

With tetrachloromethane; silver nitrate; triethylamine; triphenylphosphine; In acetic acid;

DOI:10.1007/BF00515002

Reference yield:

2-(methylthio)-5-phenylpyrimidine (31408-20-5) → p-Amyloxyphenyl p-(5-Phenyl-2-pyrimidylcarbonyloxy)benzoate (106307-69-1)

Guidance literature:

Multi-step reaction with 4 steps

1: 30 percent / 30percent hydrogen peroxide / acetic acid / 6 h / 60 °C

2: 70 percent / N-methylpyrrolidone / 1.) room temp. 1 h, 2.) 50 deg C, 2 h, 3.) 60 deg C, 4 h

3: 71 percent / 15percent aq. sodium hydroxide / 0.5 h / Heating

4: 37 percent / triphenylphosphine, carbon tetrachloride, triethylamine / 10 h / Ambient temperature

With 1-methyl-pyrrolidin-2-one; tetrachloromethane; sodium hydroxide; dihydrogen peroxide; triethylamine; triphenylphosphine; In acetic acid;

DOI:10.1007/BF00515002

upstream raw materials:

2-Cyano-5-phenylpyrimidine

2-Tribromomethyl-5-phenylpyrimidine

2-Methylsulfonyl-5-phenylpyrimidine

2-(methylthio)-5-phenylpyrimidine