Multi-step reaction with 8 steps
1: SO2 / benzene; H2O / 20 h / 10 °C
2: 1.) O3, 2.) thiourea, / 1.) C2H2Cl2, from -70 to -60 deg C, 2.) CH2Cl2, MeOH, from -50 to -20 deg C
3: sodium borohydride / benzene; ethanol / 0.5 h
4: pyridine / 1.) 0 deg C, 1 h, 2.) 10 deg C, 15 h
5: lithium carbonate, lithium bromide / dimethylformamide / 1.) 40 deg C, 1 h, 18-20 deg C, 16 h
6: 2,6-di-tert-butyl-4-methylphenol, sodium bicarbonate / dimethylformamide / 4 h / 75 °C
7: KOH / diethyl ether; methanol / 1 h
8: pyridine / 15 h / 18 - 20 °C
With
pyridine; potassium hydroxide; sodium tetrahydroborate; 2,6-di-tert-butyl-4-methyl-phenol; sulfur dioxide; lithium carbonate; sodium hydrogencarbonate; ozone; thiourea; lithium bromide;
In
methanol; diethyl ether; ethanol; water; N,N-dimethyl-formamide; benzene;