[(S)-((2R,3aR)-6,6-Dimethyl-hexahydro-pyrrolo[1,2-b]isoxazol-2-yl)-phenyl-phosphinoyl]-acetic acid (1R,2S,5R)-2-isopropyl-5-methyl-cyclohexyl ester

Base Information

• Chemical Name: [(S)-((2R,3aR)-6,6-Dimethyl-hexahydro-pyrrolo[1,2-b]isoxazol-2-yl)-phenyl-phosphinoyl]-acetic acid (1R,2S,5R)-2-isopropyl-5-methyl-cyclohexyl ester
• CAS No.: 134929-99-0
• Molecular Formula: C₂₆H₄₀NO₄P
• Molecular Weight: 461.582
• Mol file: 134929-99-0.mol

Synonyms:

Chemical Property of [(S)-((2R,3aR)-6,6-Dimethyl-hexahydro-pyrrolo[1,2-b]isoxazol-2-yl)-phenyl-phosphinoyl]-acetic acid (1R,2S,5R)-2-isopropyl-5-methyl-cyclohexyl ester

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of [(S)-((2R,3aR)-6,6-Dimethyl-hexahydro-pyrrolo[1,2-b]isoxazol-2-yl)-phenyl-phosphinoyl]-acetic acid (1R,2S,5R)-2-isopropyl-5-methyl-cyclohexyl ester

There total 1 articles about [(S)-((2R,3aR)-6,6-Dimethyl-hexahydro-pyrrolo[1,2-b]isoxazol-2-yl)-phenyl-phosphinoyl]-acetic acid (1R,2S,5R)-2-isopropyl-5-methyl-cyclohexyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

5,5-Dimethyl-1-pyrroline N-oxide (3317-61-1) + (+)-(RP)-<(menthoxycarbonyl)methyl>phenylvinylphosphine oxide (134369-22-5) → [(S)-((2R,3aR)-6,6-Dimethyl-hexahydro-pyrrolo[1,2-b]isoxazol-2-yl)-phenyl-phosphinoyl]-acetic acid (1R,2S,5R)-2-isopropyl-5-methyl-cyclohexyl ester (134929-99-0) + [(S)-((2S,3aS)-6,6-Dimethyl-hexahydro-pyrrolo[1,2-b]isoxazol-2-yl)-phenyl-phosphinoyl]-acetic acid (1R,2S,5R)-2-isopropyl-5-methyl-cyclohexyl ester (134930-00-0)

Guidance literature:

In dichloromethane; at 25 ℃; for 168h; Yield given. Yields of byproduct given. Title compound not separated from byproducts;

DOI:10.1021/jo00014a011

upstream raw materials:

5,5-Dimethyl-1-pyrroline N-oxide

(+)-(R_P)-<(menthoxycarbonyl)methyl>phenylvinylphosphine oxide