2-(4-chlorophenyl)-3,4-dihydro-2H-thieno<3,2-b><1,4>thiazine

Base Information

Chemical Name:2-(4-chlorophenyl)-3,4-dihydro-2H-thieno<3,2-b><1,4>thiazine
CAS No.:220965-67-3
Molecular Formula:C₁₂H₁₀ClNS₂
Molecular Weight:267.803
Hs Code.:

Synonyms:

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Chemical Property of 2-(4-chlorophenyl)-3,4-dihydro-2H-thieno<3,2-b><1,4>thiazine

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Technology Process of 2-(4-chlorophenyl)-3,4-dihydro-2H-thieno<3,2-b><1,4>thiazine

There total 7 articles about 2-(4-chlorophenyl)-3,4-dihydro-2H-thieno<3,2-b><1,4>thiazine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 43.0%

: 220965-62-8
2-(4-chlorophenyl)-2H-thieno<3,2-b><1,4>thiazin-3(4H)-one

: 220965-67-3
2-(4-chlorophenyl)-3,4-dihydro-2H-thieno<3,2-b><1,4>thiazine

Guidance literature:: With lithium aluminium tetrahydride; In tetrahydrofuran; 1,4-dioxane; for 12h; Ambient temperature;
DOI:10.1002/jhet.5570350651

Reference yield:

: 5445-25-0
ethyl 2-bromo-2-(4-chlorophenyl)acetate

: 220965-67-3
2-(4-chlorophenyl)-3,4-dihydro-2H-thieno<3,2-b><1,4>thiazine

Guidance literature:: Multi-step reaction with 3 steps

1: 1.) Na₂S*9H₂O / 1.) EtOH, RT, 1 h, 2.) EtOH, reflux, 12 h

2: 60 percent / Fe, AcOH / toluene / 48 h / Heating

3: 43 percent / LiAlH₄ / dioxane; tetrahydrofuran / 12 h / Ambient temperature

With sodium sulfide; lithium aluminium tetrahydride; iron; acetic acid; In tetrahydrofuran; 1,4-dioxane; toluene;
DOI:10.1002/jhet.5570350651

Reference yield:

: 104-83-6
1-Chloro-4-(chloromethyl)benzene

: 220965-67-3
2-(4-chlorophenyl)-3,4-dihydro-2H-thieno<3,2-b><1,4>thiazine

Guidance literature:: Multi-step reaction with 5 steps

1: 1.) Na₂S*9H₂O / 1.) EtOH, RT, 1 h, 2.) EtOH, reflux, 12 h

2: 78 percent / Fe, AcOH / 1 h / 75 °C

3: 65 percent / Et₃N / toluene / 10 h / Heating

4: 3 percent / hexamethylphosphoric triamide, LDA / tetrahydrofuran / 0.5 h / -70 °C

5: 43 percent / LiAlH₄ / dioxane; tetrahydrofuran / 12 h / Ambient temperature

With N,N,N,N,N,N-hexamethylphosphoric triamide; sodium sulfide; lithium aluminium tetrahydride; iron; acetic acid; triethylamine; lithium diisopropyl amide; In tetrahydrofuran; 1,4-dioxane; toluene;
DOI:10.1002/jhet.5570350651