N-[(1-carbamimidoyl-2-ethoxy-piperidin-3-ylcarbamoyl)-methyl]-3-(1-carbamimidoyl-piperidin-4-yl)-2-[2-(1H-tetrazol-5-yl)-phenylmethanesulfonylamino]-propionamide

Base Information

Chemical Name:N-[(1-carbamimidoyl-2-ethoxy-piperidin-3-ylcarbamoyl)-methyl]-3-(1-carbamimidoyl-piperidin-4-yl)-2-[2-(1H-tetrazol-5-yl)-phenylmethanesulfonylamino]-propionamide
CAS No.:274928-63-1
Molecular Formula:C₂₇H₄₃N₁₃O₅S
Molecular Weight:661.789
Hs Code.:

<i>N</i>-[(1-carbamimidoyl-2-ethoxy-piperidin-3-ylcarbamoyl)-methyl]-3-(1-carbamimidoyl-piperidin-4-yl)-2-[2-(1<i>H</i>-tetrazol-5-yl)-phenylmethanesulfonylamino]-propionamide

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Chemical Property of N-[(1-carbamimidoyl-2-ethoxy-piperidin-3-ylcarbamoyl)-methyl]-3-(1-carbamimidoyl-piperidin-4-yl)-2-[2-(1H-tetrazol-5-yl)-phenylmethanesulfonylamino]-propionamide

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Technology Process of N-[(1-carbamimidoyl-2-ethoxy-piperidin-3-ylcarbamoyl)-methyl]-3-(1-carbamimidoyl-piperidin-4-yl)-2-[2-(1H-tetrazol-5-yl)-phenylmethanesulfonylamino]-propionamide

There total 8 articles about N-[(1-carbamimidoyl-2-ethoxy-piperidin-3-ylcarbamoyl)-methyl]-3-(1-carbamimidoyl-piperidin-4-yl)-2-[2-(1H-tetrazol-5-yl)-phenylmethanesulfonylamino]-propionamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: C₄₃H₅₄N₁₄O₁₁S

: 274928-63-1
N-[(1-carbamimidoyl-2-ethoxy-piperidin-3-ylcarbamoyl)-methyl]-3-(1-carbamimidoyl-piperidin-4-yl)-2-[2-(1H-tetrazol-5-yl)-phenylmethanesulfonylamino]-propionamide

Guidance literature:: With hydrogen; palladium on activated charcoal; In ethanol; water; acetic acid;
DOI:10.1016/S0960-894X(00)00105-0

Reference yield:

: 37535-58-3
(R)-2-(tert-butoxycarbonylamino)-3-(pyridin-4-yl)propanoic acid

: 274928-63-1
N-[(1-carbamimidoyl-2-ethoxy-piperidin-3-ylcarbamoyl)-methyl]-3-(1-carbamimidoyl-piperidin-4-yl)-2-[2-(1H-tetrazol-5-yl)-phenylmethanesulfonylamino]-propionamide

Guidance literature:: Multi-step reaction with 8 steps

1: 97 percent / EDC; HOBt; DIEA / acetonitrile

2: 100 percent / H₂; aq. AcOH / PtO₂ / ethanol

3: 55 percent / DIEA; THF / Heating

4: 100 percent / HCl / ethyl acetate

5: NMM / acetonitrile

6: 1N LiOH / ethanol

7: EDC; HOBt; NMM / acetonitrile

8: H₂ / 10 percent Pd/C / ethanol; acetic acid; H₂O

With tetrahydrofuran; 4-methyl-morpholine; hydrogenchloride; lithium hydroxide; hydrogen; benzotriazol-1-ol; acetic acid; N-(3-dimethylaminopropyl)-N-ethylcarbodiimide; N-ethyl-N,N-diisopropylamine; platinum(IV) oxide; palladium on activated charcoal; In ethanol; water; acetic acid; ethyl acetate; acetonitrile; 1: coupling / 2: Hydrogenation / 3: guanylation / 4: deprotection / 5: Acylation / 6: Hydrolysis / 7: coupling / 8: Hydrogenolysis;
DOI:10.1016/S0960-894X(00)00105-0

Reference yield:

: 274928-32-4
(2-tert-butoxycarbonylamino-3-pyridin-4-yl-propionylamino)-acetic acid methyl ester

: 274928-63-1
N-[(1-carbamimidoyl-2-ethoxy-piperidin-3-ylcarbamoyl)-methyl]-3-(1-carbamimidoyl-piperidin-4-yl)-2-[2-(1H-tetrazol-5-yl)-phenylmethanesulfonylamino]-propionamide

Guidance literature:: Multi-step reaction with 7 steps

1: 100 percent / H₂; aq. AcOH / PtO₂ / ethanol

2: 55 percent / DIEA; THF / Heating

3: 100 percent / HCl / ethyl acetate

4: NMM / acetonitrile

5: 1N LiOH / ethanol

6: EDC; HOBt; NMM / acetonitrile

7: H₂ / 10 percent Pd/C / ethanol; acetic acid; H₂O

With tetrahydrofuran; 4-methyl-morpholine; hydrogenchloride; lithium hydroxide; hydrogen; benzotriazol-1-ol; acetic acid; N-(3-dimethylaminopropyl)-N-ethylcarbodiimide; N-ethyl-N,N-diisopropylamine; platinum(IV) oxide; palladium on activated charcoal; In ethanol; water; acetic acid; ethyl acetate; acetonitrile; 1: Hydrogenation / 2: guanylation / 3: deprotection / 4: Acylation / 5: Hydrolysis / 6: coupling / 7: Hydrogenolysis;
DOI:10.1016/S0960-894X(00)00105-0