(7R,13R)-4-bromo-1-hydroxy-3-methoxy-13-(3-methyl-1,2,4-oxadiazol-5-yl)-7-phenyl-9,10,13,14-tetrahydro-12H,16H-6-oxa-15-thia-9,12-diazabenzocyclotetradecene-5,8,11-trione

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Chemical Name:(7R,13R)-4-bromo-1-hydroxy-3-methoxy-13-(3-methyl-1,2,4-oxadiazol-5-yl)-7-phenyl-9,10,13,14-tetrahydro-12H,16H-6-oxa-15-thia-9,12-diazabenzocyclotetradecene-5,8,11-trione
CAS No.:1275617-12-3
Molecular Formula:C₂₄H₂₃BrN₄O₇S
Molecular Weight:591.439
Hs Code.:

(7R,13R)-4-bromo-1-hydroxy-3-methoxy-13-(3-methyl-1,2,4-oxadiazol-5-yl)-7-phenyl-9,10,13,14-tetrahydro-12H,16H-6-oxa-15-thia-9,12-diazabenzocyclotetradecene-5,8,11-trione

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Chemical Property of (7R,13R)-4-bromo-1-hydroxy-3-methoxy-13-(3-methyl-1,2,4-oxadiazol-5-yl)-7-phenyl-9,10,13,14-tetrahydro-12H,16H-6-oxa-15-thia-9,12-diazabenzocyclotetradecene-5,8,11-trione

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Technology Process of (7R,13R)-4-bromo-1-hydroxy-3-methoxy-13-(3-methyl-1,2,4-oxadiazol-5-yl)-7-phenyl-9,10,13,14-tetrahydro-12H,16H-6-oxa-15-thia-9,12-diazabenzocyclotetradecene-5,8,11-trione

There total 15 articles about (7R,13R)-4-bromo-1-hydroxy-3-methoxy-13-(3-methyl-1,2,4-oxadiazol-5-yl)-7-phenyl-9,10,13,14-tetrahydro-12H,16H-6-oxa-15-thia-9,12-diazabenzocyclotetradecene-5,8,11-trione which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1275617-55-4
C₃₂H₄₁BrN₄O₇SSi

: 1275617-12-3
(7R,13R)-4-bromo-1-hydroxy-3-methoxy-13-(3-methyl-1,2,4-oxadiazol-5-yl)-7-phenyl-9,10,13,14-tetrahydro-12H,16H-6-oxa-15-thia-9,12-diazabenzocyclotetradecene-5,8,11-trione

Guidance literature:: With ammonium fluoride; In methanol; at 20 ℃; for 0.5h; Inert atmosphere;
DOI:10.1021/jm1014023

Reference yield:

: 1275617-08-7
allyl 2-[(R)-2-amino-2-(3-methyl-1,2,4-oxadiazol-5-yl)ethylsulfanylmethyl]-6-bromo-3-[dimethyl(thexyl)silyloxy]-5-methoxybenzoate

: 1275617-12-3
(7R,13R)-4-bromo-1-hydroxy-3-methoxy-13-(3-methyl-1,2,4-oxadiazol-5-yl)-7-phenyl-9,10,13,14-tetrahydro-12H,16H-6-oxa-15-thia-9,12-diazabenzocyclotetradecene-5,8,11-trione

Guidance literature:: Multi-step reaction with 4 steps

1: 1,2-dichloro-ethane / acetonitrile / 0 °C / Inert atmosphere

2: morpholine; tetrakis(triphenylphosphine) palladium⁽⁰⁾ / tetrahydrofuran / 1 h / 0 °C / Inert atmosphere

3: triphenylphosphine; diethylazodicarboxylate / toluene / 19 h / 0 - 20 °C / Inert atmosphere

4: ammonium fluoride / methanol / 0.5 h / 20 °C / Inert atmosphere

With morpholine; ammonium fluoride; tetrakis(triphenylphosphine) palladium⁽⁰⁾; 1,2-dichloro-ethane; triphenylphosphine; diethylazodicarboxylate; In tetrahydrofuran; methanol; toluene; acetonitrile;
DOI:10.1021/jm1014023

Reference yield:

: 1275617-53-2
C₃₅H₄₇BrN₄O₈SSi

: 1275617-12-3
(7R,13R)-4-bromo-1-hydroxy-3-methoxy-13-(3-methyl-1,2,4-oxadiazol-5-yl)-7-phenyl-9,10,13,14-tetrahydro-12H,16H-6-oxa-15-thia-9,12-diazabenzocyclotetradecene-5,8,11-trione

Guidance literature:: Multi-step reaction with 3 steps

1: morpholine; tetrakis(triphenylphosphine) palladium⁽⁰⁾ / tetrahydrofuran / 1 h / 0 °C / Inert atmosphere

2: triphenylphosphine; diethylazodicarboxylate / toluene / 19 h / 0 - 20 °C / Inert atmosphere

3: ammonium fluoride / methanol / 0.5 h / 20 °C / Inert atmosphere

With morpholine; ammonium fluoride; tetrakis(triphenylphosphine) palladium⁽⁰⁾; triphenylphosphine; diethylazodicarboxylate; In tetrahydrofuran; methanol; toluene;
DOI:10.1021/jm1014023