Technology Process of (22E,24R)-24,25-dihydroxy-22-dehydrovitamin D3
There total 14 articles about (22E,24R)-24,25-dihydroxy-22-dehydrovitamin D3 which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
Multi-step reaction with 5 steps
1: 39 percent / n-butyllithium, diisopropylamine / tetrahydrofuran / 3 h / -78 °C
2: 90 percent / p-toluenesulfonic acid / benzene / 2 h / Ambient temperature
3: 1.) sodium borohydride; 2.) N,N-diisopropyl ethylamine / 1.) methanol, THF, r.t., 2 h: 2.) Ch2Cl2, r.t., 3 h
4: lithium aluminum hydride
5: 1.) ethanol, irrad., quartz cell; 2.) ref., ethanol
With
sodium tetrahydroborate; lithium aluminium tetrahydride; n-butyllithium; toluene-4-sulfonic acid; diisopropylamine; N-ethyl-N,N-diisopropylamine;
In
tetrahydrofuran; benzene;
DOI:10.1248/cpb.35.970
- Guidance literature:
-
Multi-step reaction with 5 steps
1: 39 percent / n-butyllithium, diisopropylamine / tetrahydrofuran / 3 h / -78 °C
2: 90 percent / p-toluenesulfonic acid / benzene / 2 h / Ambient temperature
3: 1.) sodium borohydride; 2.) N,N-diisopropyl ethylamine / 1.) methanol, THF, r.t., 2 h: 2.) Ch2Cl2, r.t., 3 h
4: lithium aluminum hydride
5: 1.) ethanol, irrad., quartz cell; 2.) ref., ethanol
With
sodium tetrahydroborate; lithium aluminium tetrahydride; n-butyllithium; toluene-4-sulfonic acid; diisopropylamine; N-ethyl-N,N-diisopropylamine;
In
tetrahydrofuran; benzene;
DOI:10.1248/cpb.35.970
- Guidance literature:
-
Multi-step reaction with 4 steps
1: 90 percent / p-toluenesulfonic acid / benzene / 2 h / Ambient temperature
2: 1.) sodium borohydride; 2.) N,N-diisopropyl ethylamine / 1.) methanol, THF, r.t., 2 h: 2.) Ch2Cl2, r.t., 3 h
3: lithium aluminum hydride
4: 1.) ethanol, irrad., quartz cell; 2.) ref., ethanol
With
sodium tetrahydroborate; lithium aluminium tetrahydride; toluene-4-sulfonic acid; N-ethyl-N,N-diisopropylamine;
In
benzene;
DOI:10.1248/cpb.35.970
