C₂₅H₂₂FN₃O₂

Base Information

• Chemical Name: C₂₅H₂₂FN₃O₂
• CAS No.: 1610627-28-5
• Molecular Formula: C₂₅H₂₂FN₃O₂
• Molecular Weight: 415.467
• Mol file: 1610627-28-5.mol

Synonyms:

Chemical Property of C₂₅H₂₂FN₃O₂

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of C₂₅H₂₂FN₃O₂

There total 11 articles about C₂₅H₂₂FN₃O₂ which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

ethyl 1H-pyrrole-2-carboxylate (2199-43-1) → C25H22FN3O2 (1610627-28-5)

Guidance literature:

Multi-step reaction with 9 steps

1: N,N-dimethyl-formamide; acetonitrile

2: sodium hydride / N,N-dimethyl-formamide

3: hydrogen; ammonium hydroxide

4: N-ethyl-N,N-diisopropylamine / acetonitrile

5: sodium hydride / N,N-dimethyl-formamide

6: potassium acetate; palladium diacetate; triphenylphosphine / N,N-dimethyl acetamide / 150 °C / Inert atmosphere

7: hydrogenchloride / 1,4-dioxane; water / 80 °C

8: sodium hydroxide / water; ethanol / Reflux

9: N-ethyl-N,N-diisopropylamine; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / dichloromethane

With hydrogenchloride; ammonium hydroxide; hydrogen; potassium acetate; palladium diacetate; sodium hydride; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine; triphenylphosphine; sodium hydroxide; In 1,4-dioxane; ethanol; dichloromethane; N,N-dimethyl acetamide; water; N,N-dimethyl-formamide; acetonitrile;

DOI:10.1016/j.bmcl.2014.04.061

Reference yield:

ethoxymethyl (1610627-23-0) → C25H22FN3O2 (1610627-28-5)

Guidance literature:

Multi-step reaction with 4 steps

1: potassium acetate; palladium diacetate; triphenylphosphine / N,N-dimethyl acetamide / 150 °C / Inert atmosphere

2: hydrogenchloride / 1,4-dioxane; water / 80 °C

3: sodium hydroxide / water; ethanol / Reflux

4: N-ethyl-N,N-diisopropylamine; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / dichloromethane

With hydrogenchloride; potassium acetate; palladium diacetate; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine; triphenylphosphine; sodium hydroxide; In 1,4-dioxane; ethanol; dichloromethane; N,N-dimethyl acetamide; water;

DOI:10.1016/j.bmcl.2014.04.061

Reference yield:

C19H22N2O4 (1610627-24-1) → C25H22FN3O2 (1610627-28-5)

Guidance literature:

Multi-step reaction with 3 steps

1: hydrogenchloride / 1,4-dioxane; water / 80 °C

2: sodium hydroxide / water; ethanol / Reflux

3: N-ethyl-N,N-diisopropylamine; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / dichloromethane

With hydrogenchloride; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine; sodium hydroxide; In 1,4-dioxane; ethanol; dichloromethane; water;

DOI:10.1016/j.bmcl.2014.04.061

upstream raw materials:

ethyl 1H-pyrrole-2-carboxylate

ethyl 4-cyano-1H-pyrrole-2-carboxylate

C₉H₁₀N₂O₂

C₉H₁₄N₂O₂