{1-[2'-(4-methoxy-phenyl)-3H,3'H-[2,5']bibenzoimidazolyl-5-yl]-pyrrolidin-3-yl}-carbamic acid tert-butyl ester

Base Information

• Chemical Name: {1-[2'-(4-methoxy-phenyl)-3H,3'H-[2,5']bibenzoimidazolyl-5-yl]-pyrrolidin-3-yl}-carbamic acid tert-butyl ester
• CAS No.: 391903-26-7
• Molecular Formula: C₃₀H₃₂N₆O₃
• Molecular Weight: 524.622
• Mol file: 391903-26-7.mol

Synonyms:

Chemical Property of {1-[2'-(4-methoxy-phenyl)-3H,3'H-[2,5']bibenzoimidazolyl-5-yl]-pyrrolidin-3-yl}-carbamic acid tert-butyl ester

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of {1-[2'-(4-methoxy-phenyl)-3H,3'H-[2,5']bibenzoimidazolyl-5-yl]-pyrrolidin-3-yl}-carbamic acid tert-butyl ester

There total 13 articles about {1-[2'-(4-methoxy-phenyl)-3H,3'H-[2,5']bibenzoimidazolyl-5-yl]-pyrrolidin-3-yl}-carbamic acid tert-butyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

5-chloro-2-nitroaniline (1635-61-6) → {1-[2'-(4-methoxy-phenyl)-3H,3'H-[2,5']bibenzoimidazolyl-5-yl]-pyrrolidin-3-yl}-carbamic acid tert-butyl ester (391903-26-7)

Guidance literature:

Multi-step reaction with 3 steps

1: 91 percent / potassium carbonate / dimethylformamide / 3 h / 90 °C

2: hydrogen / 5 percent Pd/C / ethanol / 3 h / 20 °C

3: sodium pyrosulfite / ethanol; H₂O / 5 h / Heating

With sodium disulfite; hydrogen; potassium carbonate; palladium on activated charcoal; In ethanol; water; N,N-dimethyl-formamide;

DOI:10.1016/S0968-0896(01)00170-5

Reference yield:

3,4-dinitrobenzoyl chloride (24376-18-9) → {1-[2'-(4-methoxy-phenyl)-3H,3'H-[2,5']bibenzoimidazolyl-5-yl]-pyrrolidin-3-yl}-carbamic acid tert-butyl ester (391903-26-7)

Guidance literature:

Multi-step reaction with 5 steps

1: 20.3 g / pyridine / CH₂Cl₂ / 20 °C

2: hydrogen / 5 percent Pd/C / ethanol / 3 h / 20 °C

3: 1.95 g / sodium pyrosulfite / ethanol; H₂O / 4 h / Heating

4: 88 percent / LiAlH₄ / tetrahydrofuran; diethyl ether / 6 h

5: sodium pyrosulfite / ethanol; H₂O / 5 h / Heating

With pyridine; sodium disulfite; lithium aluminium tetrahydride; hydrogen; palladium on activated charcoal; In tetrahydrofuran; diethyl ether; ethanol; dichloromethane; water;

DOI:10.1016/S0968-0896(01)00170-5

Reference yield:

3-(tert-butoxycarbonylamino)pyrrolidine (99724-19-3,140629-77-2) → {1-[2'-(4-methoxy-phenyl)-3H,3'H-[2,5']bibenzoimidazolyl-5-yl]-pyrrolidin-3-yl}-carbamic acid tert-butyl ester (391903-26-7)

Guidance literature:

Multi-step reaction with 3 steps

1: 91 percent / potassium carbonate / dimethylformamide / 3 h / 90 °C

2: hydrogen / 5 percent Pd/C / ethanol / 3 h / 20 °C

3: sodium pyrosulfite / ethanol; H₂O / 5 h / Heating

With sodium disulfite; hydrogen; potassium carbonate; palladium on activated charcoal; In ethanol; water; N,N-dimethyl-formamide;

DOI:10.1016/S0968-0896(01)00170-5

upstream raw materials:

2-(4-methoxyphenyl)-1H-benzo[d]imidazole-6-carbaldehyde

3,4-dinitrobenzoic acid

5-chloro-2-nitroaniline

ethyl 3,4-diaminobenzoate