2-Fluorobenzohydroxamic acid

Base Information

• Chemical Name: 2-Fluorobenzohydroxamic acid
• CAS No.: 17512-70-8
• Molecular Formula: C7H6 F N O2
• Molecular Weight: 155.129
• NSC Number: 111685
• DSSTox Substance ID: DTXSID90296814
• Nikkaji Number: J976.713D
• Wikidata: Q82037595
• ChEMBL ID: CHEMBL2436429
• Mol file: 17512-70-8.mol

Synonyms:2-fluoro-n-hydroxybenzamide;17512-70-8;2-FLUOROBENZOHYDROXAMIC ACID;Benzamide, 2-fluoro-N-hydroxy-;NSC 111685;2-fluorobenzenecarbohydroxamic acid;NSC111685;N-Hydroxy-2-fluorobenzamide;SCHEMBL298653;CHEMBL2436429;DTXSID90296814;MFCD00040200;AKOS000183505;NSC-111685;CS-0343748;EN300-1294299

Chemical Property of 2-Fluorobenzohydroxamic acid

Chemical Property:

• Boiling Point: °Cat760mmHg
• Flash Point: °C
• Density: 1.349g/cm³
• XLogP3: 1
• Hydrogen Bond Donor Count: 2
• Hydrogen Bond Acceptor Count: 3
• Rotatable Bond Count: 1
• Exact Mass: 155.03825660
• Heavy Atom Count: 11
• Complexity: 151

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C1=CC=C(C(=C1)C(=O)NO)F

Technology Process of 2-Fluorobenzohydroxamic acid

There total 4 articles about 2-Fluorobenzohydroxamic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 88.0%

2-Fluorobenzoyl chloride (393-52-2) → 2-fluoro-N-hydroxybenzamide (17512-70-8)

Guidance literature:

With hydroxylamine hydrochloride; potassium carbonate; In water; ethyl acetate; at 0 - 20 ℃; for 16h;

DOI:10.1039/c8ob00490k

Reference yield: 70.0%

o-fluoro-benzoic acid (445-29-4) → 2-fluoro-N-hydroxybenzamide (17512-70-8)

Guidance literature:

With hydroxylamine hydrochloride; 1,1'-carbonyldiimidazole; In N,N-dimethyl-formamide; for 20h;

DOI:10.1016/j.bmcl.2013.08.081

Reference yield:

methyl 2-fluorobenzoate (394-35-4) → 2-fluoro-N-hydroxybenzamide (17512-70-8)

Guidance literature:

With potassium hydroxide; hydroxylamine hydrochloride;

DOI:10.1021/ja01872a022

upstream raw materials:

methyl 2-fluorobenzoate

2-Fluorobenzoyl chloride

o-fluoro-benzoic acid

Downstream raw materials:

2-(2-fluorophenyl)-5-phenyloxazole

N-(2-fluorophenyl)formamide

2-(2-fluorophenyl)-4H-benzo[d][1,3]oxazin-4-one