(S)-2-[(S)-2-((S)-2-Amino-3-phenyl-propionylamino)-3-(4-tert-butoxy-phenyl)-propionylamino]-propionic acid phenyl ester; compound with toluene-4-sulfonic acid

Base Information

• Chemical Name: (S)-2-[(S)-2-((S)-2-Amino-3-phenyl-propionylamino)-3-(4-tert-butoxy-phenyl)-propionylamino]-propionic acid phenyl ester; compound with toluene-4-sulfonic acid
• CAS No.: 86095-92-3
• Molecular Formula: C₇H₈O₃S*C₃₁H₃₇N₃O₅
• Molecular Weight: 703.857
• Mol file: 86095-92-3.mol

Synonyms:

Chemical Property of (S)-2-[(S)-2-((S)-2-Amino-3-phenyl-propionylamino)-3-(4-tert-butoxy-phenyl)-propionylamino]-propionic acid phenyl ester; compound with toluene-4-sulfonic acid

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (S)-2-[(S)-2-((S)-2-Amino-3-phenyl-propionylamino)-3-(4-tert-butoxy-phenyl)-propionylamino]-propionic acid phenyl ester; compound with toluene-4-sulfonic acid

There total 2 articles about (S)-2-[(S)-2-((S)-2-Amino-3-phenyl-propionylamino)-3-(4-tert-butoxy-phenyl)-propionylamino]-propionic acid phenyl ester; compound with toluene-4-sulfonic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

N-(benzyloxycarbonyl)-phenylalanine-N-hydroxysuccinimide ester (3397-32-8) → (S)-2-[(S)-2-((S)-2-Amino-3-phenyl-propionylamino)-3-(4-tert-butoxy-phenyl)-propionylamino]-propionic acid phenyl ester; compound with toluene-4-sulfonic acid (86095-92-3)

Guidance literature:

Multi-step reaction with 2 steps

1: 83 percent / N-methyl-morpholin / Ambient temperature

2: H₂ / 10percent Pd/c / dimethylformamide / 18 h

With 4-methyl-morpholine; hydrogen; palladium on activated charcoal; In N,N-dimethyl-formamide;

DOI:10.1016/S0040-4020(01)97641-0

Reference yield:

p-toluenesulfonic acid monohydrate (6192-52-5) + Z-Phe-Tyr(But)-Ala-OPh (86095-64-9) → (S)-2-[(S)-2-((S)-2-Amino-3-phenyl-propionylamino)-3-(4-tert-butoxy-phenyl)-propionylamino]-propionic acid phenyl ester; compound with toluene-4-sulfonic acid (86095-92-3)

Guidance literature:

With hydrogen; palladium on activated charcoal; In N,N-dimethyl-formamide; for 18h;

DOI:10.1016/S0040-4020(01)97641-0

Reference yield: 83.0%

N-(benzyloxycarbonyl)-phenylalanine-N-hydroxysuccinimide ester (3397-32-8) + (S)-2-[(S)-2-((S)-2-Amino-3-phenyl-propionylamino)-3-(4-tert-butoxy-phenyl)-propionylamino]-propionic acid phenyl ester; compound with toluene-4-sulfonic acid (86095-92-3) → Z-Phe-Tyr(But)-Ala-OPh (86095-64-9)

Guidance literature:

With 4-methyl-morpholine; Ambient temperature;

DOI:10.1016/S0040-4020(01)97641-0

upstream raw materials:

p-toluenesulfonic acid monohydrate

Z-Phe-Tyr(Bu^t)-Ala-OPh

N-(benzyloxycarbonyl)-phenylalanine-N-hydroxysuccinimide ester

Downstream raw materials:

Z-Phe-Tyr(Bu^t)-Ala-OPh

Z-Phe-Phe-Tyr(Bu^t)-Ala-OPh