tert-butyl 4-(6-((6-acetyl-8-cyclopentyl-5-methyl-7-oxo-7,8-dihydropyrido[2,3-d]pyrimidin-2-yl)amino)pyridin-3-yl)piperazine-1-carboxylate

Base Information

Chemical Name:tert-butyl 4-(6-((6-acetyl-8-cyclopentyl-5-methyl-7-oxo-7,8-dihydropyrido[2,3-d]pyrimidin-2-yl)amino)pyridin-3-yl)piperazine-1-carboxylate
CAS No.:1651214-74-2
Molecular Formula:C₂₉H₃₇N₇O₄
Molecular Weight:547.657
Hs Code.:
Mol file:1651214-74-2.mol

tert-butyl 4-(6-((6-acetyl-8-cyclopentyl-5-methyl-7-oxo-7,8-dihydropyrido[2,3-d]pyrimidin-2-yl)amino)pyridin-3-yl)piperazine-1-carboxylate

Synonyms:

Suppliers and Price of tert-butyl 4-(6-((6-acetyl-8-cyclopentyl-5-methyl-7-oxo-7,8-dihydropyrido[2,3-d]pyrimidin-2-yl)amino)pyridin-3-yl)piperazine-1-carboxylate

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Total 15 raw suppliers

Chemical Property of tert-butyl 4-(6-((6-acetyl-8-cyclopentyl-5-methyl-7-oxo-7,8-dihydropyrido[2,3-d]pyrimidin-2-yl)amino)pyridin-3-yl)piperazine-1-carboxylate

Chemical Property:

Boiling Point:746.4±70.0 °C(Predicted)
PKA:5.24±0.10(Predicted)
Density:1.294±0.06 g/cm3(Predicted)

Purity/Quality:: 97% ^*data from raw suppliers

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Useful:

Uses N-Boc Palbociclib is a protected Palbociclib (P139900),(also known as compound number PD-0332991) is an experimental drug for the treatment of breast cancer being developed by Pfizer. It is a selective inhibitor of the cyclin-dependent kinases CDK4 and CDK6.

Technology Process of tert-butyl 4-(6-((6-acetyl-8-cyclopentyl-5-methyl-7-oxo-7,8-dihydropyrido[2,3-d]pyrimidin-2-yl)amino)pyridin-3-yl)piperazine-1-carboxylate

There total 23 articles about tert-butyl 4-(6-((6-acetyl-8-cyclopentyl-5-methyl-7-oxo-7,8-dihydropyrido[2,3-d]pyrimidin-2-yl)amino)pyridin-3-yl)piperazine-1-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 93.7%

: 571188-59-5
tert-butyl 4-(6-aminopyridin-3-yl)piperazine-1-carboxylate

: 1-(2-chloro-8-cyclopentyl-5-methyl-7-oxo-1,3,8-triaza-8H-naphth-6-yl)-1-ethanone

: 1651214-74-2
4-[6-(6-acetyl-8-cyclopentyl-5-methyl-7-oxo-7,8-dihydropyrido[2,3-d]pyrimidin-2-ylamino)pyridine-3-yl]piperazine-1-carboxylic acid tert-butyl ester

Guidance literature:: tert-butyl 4-(6-aminopyridin-3-yl)piperazine-1-carboxylate; With lithium hexamethyldisilazane; In tetrahydrofuran; at 10 - 20 ℃; for 1h; Inert atmosphere;

1-(2-chloro-8-cyclopentyl-5-methyl-7-oxo-1,3,8-triaza-8H-naphth-6-yl)-1-ethanone; In tetrahydrofuran; at 20 ℃; for 15h; Inert atmosphere;

Reference yield: 92.3%

: C₁₃H₁₇NO₃

: N-[5-(4-tert-butoxycarbonylpiperazin-1-yl)pyridin-2-yl]indole

: 1651214-74-2
4-[6-(6-acetyl-8-cyclopentyl-5-methyl-7-oxo-7,8-dihydropyrido[2,3-d]pyrimidin-2-ylamino)pyridine-3-yl]piperazine-1-carboxylic acid tert-butyl ester

Guidance literature:: C₁₃H₁₇NO₃; With piperidine; In N,N-dimethyl-formamide; at 115 ℃; for 4h;

N-[5-(4-tert-butoxycarbonylpiperazin-1-yl)pyridin-2-yl]indole; In N,N-dimethyl-formamide; at 90 - 95 ℃; for 7h;