2-[2-(4-tert-butylcarbamoyl-4-cyclohexyl-piperidin-1-yl)-1-(4-fluoro-benzyl)-2-oxo-ethylcarbamoyl]-4-(2,2-difluoro-ethyl)-piperazine-1-carboxylic acid tert-butyl ester

Base Information

Chemical Name:2-[2-(4-tert-butylcarbamoyl-4-cyclohexyl-piperidin-1-yl)-1-(4-fluoro-benzyl)-2-oxo-ethylcarbamoyl]-4-(2,2-difluoro-ethyl)-piperazine-1-carboxylic acid tert-butyl ester
CAS No.:363190-30-1
Molecular Formula:C₃₇H₅₆F₃N₅O₅
Molecular Weight:707.877
Hs Code.:

2-[2-(4-<i>tert</i>-butylcarbamoyl-4-cyclohexyl-piperidin-1-yl)-1-(4-fluoro-benzyl)-2-oxo-ethylcarbamoyl]-4-(2,2-difluoro-ethyl)-piperazine-1-carboxylic acid <i>tert</i>-butyl ester

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Chemical Property of 2-[2-(4-tert-butylcarbamoyl-4-cyclohexyl-piperidin-1-yl)-1-(4-fluoro-benzyl)-2-oxo-ethylcarbamoyl]-4-(2,2-difluoro-ethyl)-piperazine-1-carboxylic acid tert-butyl ester

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Technology Process of 2-[2-(4-tert-butylcarbamoyl-4-cyclohexyl-piperidin-1-yl)-1-(4-fluoro-benzyl)-2-oxo-ethylcarbamoyl]-4-(2,2-difluoro-ethyl)-piperazine-1-carboxylic acid tert-butyl ester

There total 10 articles about 2-[2-(4-tert-butylcarbamoyl-4-cyclohexyl-piperidin-1-yl)-1-(4-fluoro-benzyl)-2-oxo-ethylcarbamoyl]-4-(2,2-difluoro-ethyl)-piperazine-1-carboxylic acid tert-butyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: (R)-N-(tert-butoxycarbonyl)-4-fluorophenylalanine

: 363190-30-1
2-[2-(4-tert-butylcarbamoyl-4-cyclohexyl-piperidin-1-yl)-1-(4-fluoro-benzyl)-2-oxo-ethylcarbamoyl]-4-(2,2-difluoro-ethyl)-piperazine-1-carboxylic acid tert-butyl ester

Guidance literature:: Multi-step reaction with 5 steps

1: EDC; HOBt; DIEA / CH₂Cl₂

2: TFA / CH₂Cl₂

3: EDC; HOBt; DIEA / CH₂Cl₂

4: H₂ / Pd/C / ethanol

5: NaBH₃CN; NaOAc; TFA / methanol

With hydrogen; sodium acetate; sodium cyanoborohydride; benzotriazol-1-ol; N-(3-dimethylaminopropyl)-N-ethylcarbodiimide; N-ethyl-N,N-diisopropylamine; trifluoroacetic acid; palladium on activated charcoal; In methanol; ethanol; dichloromethane;
DOI:10.1016/j.bmcl.2004.10.020

Reference yield:

: 167262-68-2
N-(t-butyloxycarbonyl)-4-phenylpiperidine-4-carboxylic acid

: 363190-30-1
2-[2-(4-tert-butylcarbamoyl-4-cyclohexyl-piperidin-1-yl)-1-(4-fluoro-benzyl)-2-oxo-ethylcarbamoyl]-4-(2,2-difluoro-ethyl)-piperazine-1-carboxylic acid tert-butyl ester

Guidance literature:: Multi-step reaction with 9 steps

1: H₂ / Rh/Al₂O₃ / methanol / 70 °C / 3620.04 Torr

2: (COCl)2; DMF / CH₂Cl₂

3: CH₂Cl₂

4: TFA / CH₂Cl₂

5: EDC; HOBt; DIEA / CH₂Cl₂

6: TFA / CH₂Cl₂

7: EDC; HOBt; DIEA / CH₂Cl₂

8: H₂ / Pd/C / ethanol

9: NaBH₃CN; NaOAc; TFA / methanol

With oxalyl dichloride; hydrogen; sodium acetate; sodium cyanoborohydride; benzotriazol-1-ol; N-(3-dimethylaminopropyl)-N-ethylcarbodiimide; N-ethyl-N,N-diisopropylamine; N,N-dimethyl-formamide; trifluoroacetic acid; palladium on activated charcoal; Rh/Al₂O₃; In methanol; ethanol; dichloromethane;
DOI:10.1016/j.bmcl.2004.10.020

Reference yield:

: 4-phenyl-4-piperidinecarboxylic acid 4-methylbenzenesulfonate

: 363190-30-1
2-[2-(4-tert-butylcarbamoyl-4-cyclohexyl-piperidin-1-yl)-1-(4-fluoro-benzyl)-2-oxo-ethylcarbamoyl]-4-(2,2-difluoro-ethyl)-piperazine-1-carboxylic acid tert-butyl ester

Guidance literature:: Multi-step reaction with 10 steps

1: NaOH / dioxane

2: H₂ / Rh/Al₂O₃ / methanol / 70 °C / 3620.04 Torr

3: (COCl)2; DMF / CH₂Cl₂

4: CH₂Cl₂

5: TFA / CH₂Cl₂

6: EDC; HOBt; DIEA / CH₂Cl₂

7: TFA / CH₂Cl₂

8: EDC; HOBt; DIEA / CH₂Cl₂

9: H₂ / Pd/C / ethanol

10: NaBH₃CN; NaOAc; TFA / methanol

With sodium hydroxide; oxalyl dichloride; hydrogen; sodium acetate; sodium cyanoborohydride; benzotriazol-1-ol; N-(3-dimethylaminopropyl)-N-ethylcarbodiimide; N-ethyl-N,N-diisopropylamine; N,N-dimethyl-formamide; trifluoroacetic acid; palladium on activated charcoal; Rh/Al₂O₃; In 1,4-dioxane; methanol; ethanol; dichloromethane;
DOI:10.1016/j.bmcl.2004.10.020