{1-benzyl-2-hydroxy-3-[isobutyl-(2-methanesulfonyl-benzothiazole-6-sulfonyl)-amino]-propyl}-carbamic acid hexahydro-furo[2,3-b]furan-3-yl ester

Base Information

Chemical Name:{1-benzyl-2-hydroxy-3-[isobutyl-(2-methanesulfonyl-benzothiazole-6-sulfonyl)-amino]-propyl}-carbamic acid hexahydro-furo[2,3-b]furan-3-yl ester
CAS No.:1000287-01-3
Molecular Formula:C₂₉H₃₇N₃O₉S₃
Molecular Weight:667.825
Hs Code.:

{1-benzyl-2-hydroxy-3-[isobutyl-(2-methanesulfonyl-benzothiazole-6-sulfonyl)-amino]-propyl}-carbamic acid hexahydro-furo[2,3-b]furan-3-yl ester

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Chemical Property of {1-benzyl-2-hydroxy-3-[isobutyl-(2-methanesulfonyl-benzothiazole-6-sulfonyl)-amino]-propyl}-carbamic acid hexahydro-furo[2,3-b]furan-3-yl ester

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Technology Process of {1-benzyl-2-hydroxy-3-[isobutyl-(2-methanesulfonyl-benzothiazole-6-sulfonyl)-amino]-propyl}-carbamic acid hexahydro-furo[2,3-b]furan-3-yl ester

There total 5 articles about {1-benzyl-2-hydroxy-3-[isobutyl-(2-methanesulfonyl-benzothiazole-6-sulfonyl)-amino]-propyl}-carbamic acid hexahydro-furo[2,3-b]furan-3-yl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 473739-27-4
2-Methylsulfanyl-benzothiazole-6-sulfonic acid ((2R,3S)-3-amino-2-hydroxy-4-phenyl-butyl)-isobutyl-amide

: 1000287-01-3
{1-benzyl-2-hydroxy-3-[isobutyl-(2-methanesulfonyl-benzothiazole-6-sulfonyl)-amino]-propyl}-carbamic acid hexahydro-furo[2,3-b]furan-3-yl ester

Guidance literature:: Multi-step reaction with 2 steps

1: triethylamine / CH₂Cl₂ / 3 h / 20 °C

2: MCPBA / CH₂Cl₂

With triethylamine; 3-chloro-benzenecarboperoxoic acid; In dichloromethane;
DOI:10.1021/jm049454n

Reference yield:

: 473739-21-8
{(1S,2R)-1-Benzyl-2-hydroxy-3-[isobutyl-(2-methylsulfanyl-benzothiazole-6-sulfonyl)-amino]-propyl}-carbamic acid tert-butyl ester

: 1000287-01-3
{1-benzyl-2-hydroxy-3-[isobutyl-(2-methanesulfonyl-benzothiazole-6-sulfonyl)-amino]-propyl}-carbamic acid hexahydro-furo[2,3-b]furan-3-yl ester

Guidance literature:: Multi-step reaction with 3 steps

1: Acid hydrolysis

2: triethylamine / CH₂Cl₂ / 3 h / 20 °C

3: MCPBA / CH₂Cl₂

With triethylamine; 3-chloro-benzenecarboperoxoic acid; In dichloromethane;
DOI:10.1021/jm049454n

Reference yield:

: 615-22-5
2-methylmercaptobenzothiazole

: 1000287-01-3
{1-benzyl-2-hydroxy-3-[isobutyl-(2-methanesulfonyl-benzothiazole-6-sulfonyl)-amino]-propyl}-carbamic acid hexahydro-furo[2,3-b]furan-3-yl ester

Guidance literature:: Multi-step reaction with 5 steps

1.1: ClSO₃H

1.2: SOCl₂

2.1: triethylamine

3.1: Acid hydrolysis

4.1: triethylamine / CH₂Cl₂ / 3 h / 20 °C

5.1: MCPBA / CH₂Cl₂

With chlorosulfonic acid; triethylamine; 3-chloro-benzenecarboperoxoic acid; In dichloromethane;
DOI:10.1021/jm049454n