Isopropyl-{(3S,4S)-4-methoxy-6-[(3aS,4R,6R,7R,7aS)-4-methyl-6-(2-nitro-benzyloxy)-2-oxo-tetrahydro-[1,3]dioxolo[4,5-c]pyran-7-yloxy]-tetrahydro-pyran-3-yl}-carbamic acid 9H-fluoren-9-ylmethyl ester

Base Information

Chemical Name:Isopropyl-{(3S,4S)-4-methoxy-6-[(3aS,4R,6R,7R,7aS)-4-methyl-6-(2-nitro-benzyloxy)-2-oxo-tetrahydro-[1,3]dioxolo[4,5-c]pyran-7-yloxy]-tetrahydro-pyran-3-yl}-carbamic acid 9H-fluoren-9-ylmethyl ester
CAS No.:141805-59-6
Molecular Formula:C₃₈H₄₂N₂O₁₂
Molecular Weight:718.758
Hs Code.:

Isopropyl-{(3S,4S)-4-methoxy-6-[(3aS,4R,6R,7R,7aS)-4-methyl-6-(2-nitro-benzyloxy)-2-oxo-tetrahydro-[1,3]dioxolo[4,5-c]pyran-7-yloxy]-tetrahydro-pyran-3-yl}-carbamic acid 9H-fluoren-9-ylmethyl ester

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Chemical Property of Isopropyl-{(3S,4S)-4-methoxy-6-[(3aS,4R,6R,7R,7aS)-4-methyl-6-(2-nitro-benzyloxy)-2-oxo-tetrahydro-[1,3]dioxolo[4,5-c]pyran-7-yloxy]-tetrahydro-pyran-3-yl}-carbamic acid 9H-fluoren-9-ylmethyl ester

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Technology Process of Isopropyl-{(3S,4S)-4-methoxy-6-[(3aS,4R,6R,7R,7aS)-4-methyl-6-(2-nitro-benzyloxy)-2-oxo-tetrahydro-[1,3]dioxolo[4,5-c]pyran-7-yloxy]-tetrahydro-pyran-3-yl}-carbamic acid 9H-fluoren-9-ylmethyl ester

There total 1 articles about Isopropyl-{(3S,4S)-4-methoxy-6-[(3aS,4R,6R,7R,7aS)-4-methyl-6-(2-nitro-benzyloxy)-2-oxo-tetrahydro-[1,3]dioxolo[4,5-c]pyran-7-yloxy]-tetrahydro-pyran-3-yl}-carbamic acid 9H-fluoren-9-ylmethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 132938-43-3
(3aS,4R,6R,7R,7aR)-7-Hydroxy-4-methyl-6-(2-nitro-benzyloxy)-tetrahydro-[1,3]dioxolo[4,5-c]pyran-2-one

: 141805-58-5
((3S,4S)-6-Fluoro-4-methoxy-tetrahydro-pyran-3-yl)-isopropyl-carbamic acid 9H-fluoren-9-ylmethyl ester

: 141805-59-6
Isopropyl-{(3S,4S)-4-methoxy-6-[(3aS,4R,6R,7R,7aS)-4-methyl-6-(2-nitro-benzyloxy)-2-oxo-tetrahydro-[1,3]dioxolo[4,5-c]pyran-7-yloxy]-tetrahydro-pyran-3-yl}-carbamic acid 9H-fluoren-9-ylmethyl ester

Guidance literature:: With 4 A molecular sieve; silver perchlorate; tin(ll) chloride; In tetrahydrofuran; at -78 - -20 ℃; for 7h;

Reference yield:

: 141805-59-6
Isopropyl-{(3S,4S)-4-methoxy-6-[(3aS,4R,6R,7R,7aS)-4-methyl-6-(2-nitro-benzyloxy)-2-oxo-tetrahydro-[1,3]dioxolo[4,5-c]pyran-7-yloxy]-tetrahydro-pyran-3-yl}-carbamic acid 9H-fluoren-9-ylmethyl ester

: 141805-60-9
{(3S,4S,6S)-6-[(2R,3R,4S,5R,6R)-4,5-Dihydroxy-6-methyl-2-(2-nitro-benzyloxy)-tetrahydro-pyran-3-yloxy]-4-methoxy-tetrahydro-pyran-3-yl}-isopropyl-carbamic acid 9H-fluoren-9-ylmethyl ester

Guidance literature:: With sodium hydride; In tetrahydrofuran; ethylene glycol; at 25 ℃; for 0.5h; Yield given;

Reference yield:

: 141805-59-6
Isopropyl-{(3S,4S)-4-methoxy-6-[(3aS,4R,6R,7R,7aS)-4-methyl-6-(2-nitro-benzyloxy)-2-oxo-tetrahydro-[1,3]dioxolo[4,5-c]pyran-7-yloxy]-tetrahydro-pyran-3-yl}-carbamic acid 9H-fluoren-9-ylmethyl ester

: 141805-67-6
C₅₆H₈₁N₃O₁₃SSi₂

Guidance literature:: Multi-step reaction with 9 steps

1: NaH / tetrahydrofuran; ethane-1,2-diol / 0.5 h / 25 °C

2: 1.) n-Bu₂SnO, 2.) n-Bu₃SnOMe, Br₂ / 1.) MeOH, reflux, 1.2 h, 2.) CH₂Cl₂, 25 deg C

3: 70 percent / pyridinium p-toluenesulfonate / benzene / 3 h / 25 °C

4: 100 percent / 2,6-lutidine / CH₂Cl₂ / 0.5 h / 0 to 25 deg C

5: 95 percent / i-Bu₂AlH / CH₂Cl₂ / 0.5 h / -78 °C

6: 86 percent / acetonitrile / 1.5 h / 25 °C

7: 100 percent / toluene / 1 h / 100 °C

8: 95 percent / NaSMe, EtSH / CH₂Cl₂ / 1.5 h / 25 °C

9: 90 percent / i-Pr₂EtN / CH₂Cl₂ / 1 h / 25 °C

With 2,6-dimethylpyridine; bromine; tributyltin methoxide; pyridinium p-toluenesulfonate; sodium hydride; diisobutylaluminium hydride; di(n-butyl)tin oxide; N-ethyl-N,N-diisopropylamine; ethanethiol; sodium thiomethoxide; In tetrahydrofuran; dichloromethane; ethylene glycol; toluene; acetonitrile; benzene;