(R)-ethyl 4-(4-chlorophenyl)-3-(3-{4-[4-(4-{[4-(dimethylamino)-1-(phenylthio)but-2-yl ]amino}-3-nitrophenylsulfonamido)phenyl]piperazin-1-yl}phenyl)-1-methyl-1H-pyrrole-2-carboxylate

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Chemical Name:(R)-ethyl 4-(4-chlorophenyl)-3-(3-{4-[4-(4-{[4-(dimethylamino)-1-(phenylthio)but-2-yl ]amino}-3-nitrophenylsulfonamido)phenyl]piperazin-1-yl}phenyl)-1-methyl-1H-pyrrole-2-carboxylate
CAS No.:1376190-70-3
Molecular Formula:C₄₈H₅₂ClN₇O₆S₂
Molecular Weight:922.569
Hs Code.:

(R)-ethyl 4-(4-chlorophenyl)-3-(3-{4-[4-(4-{[4-(dimethylamino)-1-(phenylthio)but-2-yl ]amino}-3-nitrophenylsulfonamido)phenyl]piperazin-1-yl}phenyl)-1-methyl-1H-pyrrole-2-carboxylate

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Chemical Property of (R)-ethyl 4-(4-chlorophenyl)-3-(3-{4-[4-(4-{[4-(dimethylamino)-1-(phenylthio)but-2-yl ]amino}-3-nitrophenylsulfonamido)phenyl]piperazin-1-yl}phenyl)-1-methyl-1H-pyrrole-2-carboxylate

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Technology Process of (R)-ethyl 4-(4-chlorophenyl)-3-(3-{4-[4-(4-{[4-(dimethylamino)-1-(phenylthio)but-2-yl ]amino}-3-nitrophenylsulfonamido)phenyl]piperazin-1-yl}phenyl)-1-methyl-1H-pyrrole-2-carboxylate

There total 5 articles about (R)-ethyl 4-(4-chlorophenyl)-3-(3-{4-[4-(4-{[4-(dimethylamino)-1-(phenylthio)but-2-yl ]amino}-3-nitrophenylsulfonamido)phenyl]piperazin-1-yl}phenyl)-1-methyl-1H-pyrrole-2-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 76.0%

: 64-17-5
ethanol

: 1376190-74-7
(R)-4-(4-chlorophenyl)-3-(3-(4-(4-(4-((4-(dimethylamino)-1-(phenylthio)butan-2-yl)amino)-3-nitrophenylsulfonamido)phenyl)piperazin-1-yl)phenyl)-1-methyl-1H-pyrrole-2-carboxylic acid

: 1376190-70-3
(R)-ethyl 4-(4-chlorophenyl)-3-(3-{4-[4-(4-{[4-(dimethylamino)-1-(phenylthio)but-2-yl ]amino}-3-nitrophenylsulfonamido)phenyl]piperazin-1-yl}phenyl)-1-methyl-1H-pyrrole-2-carboxylate

Guidance literature:: With dmap; diisopropyl-carbodiimide; In tetrahydrofuran; for 8h; Inert atmosphere;
DOI:10.1021/jm300178u

Reference yield:

: 696-41-3
m-iodobenzaldehyde

: 1376190-70-3
(R)-ethyl 4-(4-chlorophenyl)-3-(3-{4-[4-(4-{[4-(dimethylamino)-1-(phenylthio)but-2-yl ]amino}-3-nitrophenylsulfonamido)phenyl]piperazin-1-yl}phenyl)-1-methyl-1H-pyrrole-2-carboxylate

Guidance literature:: Multi-step reaction with 9 steps

1: potassium carbonate / methanol / Reflux; Inert atmosphere

2: potassium tert-butylate / tetrahydrofuran; N,N-dimethyl-formamide / 1 h / 0 °C / Inert atmosphere

3: potassium carbonate / N,N-dimethyl-formamide / 4 h / 20 °C / Inert atmosphere

4: copper(l) iodide; potassium carbonate; L-proline / dimethyl sulfoxide / 80 °C / Inert atmosphere

5: potassium hydroxide / tetrahydrofuran; methanol; water / Reflux; Inert atmosphere

6: palladium 10% on activated carbon; hydrogen / methanol; dichloromethane / 20 °C / 760.05 Torr / Inert atmosphere

7: pyridine / 0 °C / Inert atmosphere

8: N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide / Inert atmosphere

9: dmap; diisopropyl-carbodiimide / tetrahydrofuran / 8 h / Inert atmosphere

With pyridine; dmap; copper(l) iodide; palladium 10% on activated carbon; potassium tert-butylate; hydrogen; potassium carbonate; N-ethyl-N,N-diisopropylamine; L-proline; potassium hydroxide; diisopropyl-carbodiimide; In tetrahydrofuran; methanol; dichloromethane; water; dimethyl sulfoxide; N,N-dimethyl-formamide;
DOI:10.1021/jm300178u

Reference yield:

: 140-53-4
p-chlorobenzyl cyanide

: 1376190-70-3
(R)-ethyl 4-(4-chlorophenyl)-3-(3-{4-[4-(4-{[4-(dimethylamino)-1-(phenylthio)but-2-yl ]amino}-3-nitrophenylsulfonamido)phenyl]piperazin-1-yl}phenyl)-1-methyl-1H-pyrrole-2-carboxylate

Guidance literature:: Multi-step reaction with 9 steps

1: potassium carbonate / methanol / Reflux; Inert atmosphere

2: potassium tert-butylate / tetrahydrofuran; N,N-dimethyl-formamide / 1 h / 0 °C / Inert atmosphere

3: potassium carbonate / N,N-dimethyl-formamide / 4 h / 20 °C / Inert atmosphere

4: copper(l) iodide; potassium carbonate; L-proline / dimethyl sulfoxide / 80 °C / Inert atmosphere

5: potassium hydroxide / tetrahydrofuran; methanol; water / Reflux; Inert atmosphere

6: palladium 10% on activated carbon; hydrogen / methanol; dichloromethane / 20 °C / 760.05 Torr / Inert atmosphere

7: pyridine / 0 °C / Inert atmosphere

8: N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide / Inert atmosphere

9: dmap; diisopropyl-carbodiimide / tetrahydrofuran / 8 h / Inert atmosphere

With pyridine; dmap; copper(l) iodide; palladium 10% on activated carbon; potassium tert-butylate; hydrogen; potassium carbonate; N-ethyl-N,N-diisopropylamine; L-proline; potassium hydroxide; diisopropyl-carbodiimide; In tetrahydrofuran; methanol; dichloromethane; water; dimethyl sulfoxide; N,N-dimethyl-formamide;
DOI:10.1021/jm300178u