9-fluoro-3,7-dihydro-3-methyl-6-(N'-methylene-3-nitrobenzohydrazide) 10-(4-methyl piperazin-1-yl)-2H-[1,4]oxazino[2,3,4-ij]quinolin-7-one

Base Information

• Chemical Name: 9-fluoro-3,7-dihydro-3-methyl-6-(N'-methylene-3-nitrobenzohydrazide) 10-(4-methyl piperazin-1-yl)-2H-[1,4]oxazino[2,3,4-ij]quinolin-7-one
• CAS No.: 1315249-15-0
• Molecular Formula: C₂₅H₂₅FN₆O₅
• Molecular Weight: 508.509
• Mol file: 1315249-15-0.mol

Synonyms:

Chemical Property of 9-fluoro-3,7-dihydro-3-methyl-6-(N'-methylene-3-nitrobenzohydrazide) 10-(4-methyl piperazin-1-yl)-2H-[1,4]oxazino[2,3,4-ij]quinolin-7-one

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 9-fluoro-3,7-dihydro-3-methyl-6-(N'-methylene-3-nitrobenzohydrazide) 10-(4-methyl piperazin-1-yl)-2H-[1,4]oxazino[2,3,4-ij]quinolin-7-one

There total 3 articles about 9-fluoro-3,7-dihydro-3-methyl-6-(N'-methylene-3-nitrobenzohydrazide) 10-(4-methyl piperazin-1-yl)-2H-[1,4]oxazino[2,3,4-ij]quinolin-7-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 56.0%

(+/-)-9-fluoro-2,3-dihydro-3-methyl-10-(4-methyl-1-piperazinyl)-7-oxo-7H-pyrido[1,2,3-de]-1,4-benzoxazine-6-carboxylhydrazide (1211989-50-2) + 3-nitro-benzaldehyde (99-61-6) → 9-fluoro-3,7-dihydro-3-methyl-6-(N'-methylene-3-nitrobenzohydrazide) 10-(4-methyl piperazin-1-yl)-2H-[1,4]oxazino[2,3,4-ij]quinolin-7-one (1315249-15-0)

Guidance literature:

With sulfuric acid; In ethanol; for 0.25h; Irradiation;

DOI:10.1007/s00044-011-9655-8

Reference yield:

ethyl (+/-)-9-fluoro-2,3-dihydro-3-methyl-10-(4-methyl-1-piperazinyl)-7-oxo-7H-pyrido[1,2,3-de]-1,4-benzoxazine-6-carboxylate (107884-32-2,177472-30-9) → 9-fluoro-3,7-dihydro-3-methyl-6-(N'-methylene-3-nitrobenzohydrazide) 10-(4-methyl piperazin-1-yl)-2H-[1,4]oxazino[2,3,4-ij]quinolin-7-one (1315249-15-0)

Guidance literature:

Multi-step reaction with 2 steps

1: hydrazine hydrate / ethanol / Reflux

2: sulfuric acid / ethanol / 0.25 h / Irradiation

With sulfuric acid; hydrazine hydrate; In ethanol;

DOI:10.1007/s00044-011-9655-8

Reference yield:

ofloxacin (82419-36-1,83380-47-6) → 9-fluoro-3,7-dihydro-3-methyl-6-(N'-methylene-3-nitrobenzohydrazide) 10-(4-methyl piperazin-1-yl)-2H-[1,4]oxazino[2,3,4-ij]quinolin-7-one (1315249-15-0)

Guidance literature:

Multi-step reaction with 3 steps

1: sulfuric acid / 48 h / Reflux

2: hydrazine hydrate / ethanol / Reflux

3: sulfuric acid / ethanol / 0.25 h / Irradiation

With sulfuric acid; hydrazine hydrate; In ethanol;

DOI:10.1007/s00044-011-9655-8

upstream raw materials:

ethyl (+/-)-9-fluoro-2,3-dihydro-3-methyl-10-(4-methyl-1-piperazinyl)-7-oxo-7H-pyrido[1,2,3-de]-1,4-benzoxazine-6-carboxylate

(+/-)-9-fluoro-2,3-dihydro-3-methyl-10-(4-methyl-1-piperazinyl)-7-oxo-7H-pyrido[1,2,3-de]-1,4-benzoxazine-6-carboxylhydrazide

3-nitro-benzaldehyde

ofloxacin

Refernces