(2R/S,3S)-3-<amino>-2-hydroxy-4-phenyl-1-(N-prolylisoleucinylphenylalanine methyl ester)butane

Base Information

Chemical Name:(2R/S,3S)-3-<amino>-2-hydroxy-4-phenyl-1-(N-prolylisoleucinylphenylalanine methyl ester)butane
CAS No.:132234-39-0
Molecular Formula:C₄₅H₅₅N₇O₈
Molecular Weight:821.974
Hs Code.:

(2R/S,3S)-3-<<N-(2-quinolylcarbonyl)asparaginyl>amino>-2-hydroxy-4-phenyl-1-(N-prolylisoleucinylphenylalanine methyl ester)butane

Synonyms:

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (2R/S,3S)-3-<amino>-2-hydroxy-4-phenyl-1-(N-prolylisoleucinylphenylalanine methyl ester)butane

Chemical Property:

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Technology Process of (2R/S,3S)-3-<amino>-2-hydroxy-4-phenyl-1-(N-prolylisoleucinylphenylalanine methyl ester)butane

There total 7 articles about (2R/S,3S)-3-<amino>-2-hydroxy-4-phenyl-1-(N-prolylisoleucinylphenylalanine methyl ester)butane which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 132234-37-8
CbzAsnPheCH₂Cl

: 132234-39-0,137253-06-6,143395-68-0
(2R/S,3S)-3-<amino>-2-hydroxy-4-phenyl-1-(N-prolylisoleucinylphenylalanine methyl ester)butane

Guidance literature:: Multi-step reaction with 4 steps

1: NaI, NaHCO₃ / dimethylformamide / 18 h / Ambient temperature

2: NaBH₄ / methanol

3: H₂, p-toluenesulfonic acid / 10percent Pd(OH)2/C / ethanol / 4 h

4: 1.) hydroxybenzotriazole (HOBt), EDCI, 2.) N-methylmorpholine (NMM) / 1.) DMF, 40 min, 2.) DMF, a) 0 deg C, 2 h, b) RT, overnight

With 4-methyl-morpholine; sodium tetrahydroborate; hydrogen; sodium hydrogencarbonate; benzotriazol-1-ol; toluene-4-sulfonic acid; sodium iodide; palladium dihydroxide; In methanol; ethanol; N,N-dimethyl-formamide;
DOI:10.1021/jm00099a008

Reference yield:

: 132234-38-9,137253-05-5,143395-66-8
(2R/S,3S)-3-<amino>-2-hydroxy-4-phenyl-1-(N-prolylisoleucinylphenylalanine methyl ester)butane

: 132234-39-0,137253-06-6,143395-68-0
(2R/S,3S)-3-<amino>-2-hydroxy-4-phenyl-1-(N-prolylisoleucinylphenylalanine methyl ester)butane

Guidance literature:: Multi-step reaction with 2 steps

1: H₂, p-toluenesulfonic acid / 10percent Pd(OH)2/C / ethanol / 4 h

2: 1.) hydroxybenzotriazole (HOBt), EDCI, 2.) N-methylmorpholine (NMM) / 1.) DMF, 40 min, 2.) DMF, a) 0 deg C, 2 h, b) RT, overnight

With 4-methyl-morpholine; hydrogen; benzotriazol-1-ol; toluene-4-sulfonic acid; palladium dihydroxide; In ethanol;
DOI:10.1021/jm00099a008

Reference yield:

: (S)-2-[(2S,3S)-2-({(S)-1-[(S)-3-((S)-2-Benzyloxycarbonylamino-3-carbamoyl-propionylamino)-2-oxo-4-phenyl-butyl]-pyrrolidine-2-carbonyl}-amino)-3-methyl-pentanoylamino]-3-phenyl-propionic acid methyl ester

: 132234-39-0,137253-06-6,143395-68-0
(2R/S,3S)-3-<amino>-2-hydroxy-4-phenyl-1-(N-prolylisoleucinylphenylalanine methyl ester)butane

Guidance literature:: Multi-step reaction with 3 steps

1: NaBH₄ / methanol

2: H₂, p-toluenesulfonic acid / 10percent Pd(OH)2/C / ethanol / 4 h

3: 1.) hydroxybenzotriazole (HOBt), EDCI, 2.) N-methylmorpholine (NMM) / 1.) DMF, 40 min, 2.) DMF, a) 0 deg C, 2 h, b) RT, overnight

With 4-methyl-morpholine; sodium tetrahydroborate; hydrogen; benzotriazol-1-ol; toluene-4-sulfonic acid; palladium dihydroxide; In methanol; ethanol;
DOI:10.1021/jm00099a008