Technology Process of (S)-3-benzyl-1-butyl-3,4-dihydro-1H-benzo[e][1,4]diazepine-2,5-dione
There total 5 articles about (S)-3-benzyl-1-butyl-3,4-dihydro-1H-benzo[e][1,4]diazepine-2,5-dione which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
With
2-thiophenylcarboxylic acid; copper(l) iodide; potassium carbonate;
In
dimethyl sulfoxide; toluene;
at 150 ℃;
for 2h;
Schlenk technique;
Inert atmosphere;
Microwave irradiation;
DOI:10.1039/c2ob07063d
- Guidance literature:
-
Multi-step reaction with 4 steps
1: thionyl chloride / dichloromethane / 1 h / Reflux
2: triethylamine / dichloromethane / 16 h / 0 - 20 °C
3: titanium(IV) isopropylate / toluene / 2 h / 120 °C / Sealed tube; Microwave irradiation; Inert atmosphere
4: potassium carbonate; 2-thiophenylcarboxylic acid; copper(l) iodide / toluene; dimethyl sulfoxide / 2 h / 150 °C / Schlenk technique; Inert atmosphere; Microwave irradiation
With
titanium(IV) isopropylate; 2-thiophenylcarboxylic acid; copper(l) iodide; thionyl chloride; potassium carbonate; triethylamine;
In
dichloromethane; dimethyl sulfoxide; toluene;
4: |Ullmann Condensation;
DOI:10.1039/c2ob07063d
- Guidance literature:
-
Multi-step reaction with 2 steps
1: titanium(IV) isopropylate / toluene / 2 h / 120 °C / Sealed tube; Microwave irradiation; Inert atmosphere
2: potassium carbonate; 2-thiophenylcarboxylic acid; copper(l) iodide / toluene; dimethyl sulfoxide / 2 h / 150 °C / Schlenk technique; Inert atmosphere; Microwave irradiation
With
titanium(IV) isopropylate; 2-thiophenylcarboxylic acid; copper(l) iodide; potassium carbonate;
In
dimethyl sulfoxide; toluene;
2: |Ullmann Condensation;
DOI:10.1039/c2ob07063d
