(1S,3S)-methyl 2-((S)-2-((9H-fluoren-9-ylmethoxycarbonyl)(2-ethoxy-2-oxoethyl)amino)propanoyl)-1-(benzyloxycarbonylaminomethyl)-2,3,4,9-tetrahydro-1Hpyrido[3,4-b]indole-3-carboxylate

Base Information

Chemical Name:(1S,3S)-methyl 2-((S)-2-((9H-fluoren-9-ylmethoxycarbonyl)(2-ethoxy-2-oxoethyl)amino)propanoyl)-1-(benzyloxycarbonylaminomethyl)-2,3,4,9-tetrahydro-1Hpyrido[3,4-b]indole-3-carboxylate
CAS No.:1427532-76-0
Molecular Formula:C₄₄H₄₄N₄O₉
Molecular Weight:772.855
Hs Code.:

(1S,3S)-methyl 2-((S)-2-((9H-fluoren-9-ylmethoxycarbonyl)(2-ethoxy-2-oxoethyl)amino)propanoyl)-1-(benzyloxycarbonylaminomethyl)-2,3,4,9-tetrahydro-1Hpyrido[3,4-b]indole-3-carboxylate

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Chemical Property of (1S,3S)-methyl 2-((S)-2-((9H-fluoren-9-ylmethoxycarbonyl)(2-ethoxy-2-oxoethyl)amino)propanoyl)-1-(benzyloxycarbonylaminomethyl)-2,3,4,9-tetrahydro-1Hpyrido[3,4-b]indole-3-carboxylate

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Technology Process of (1S,3S)-methyl 2-((S)-2-((9H-fluoren-9-ylmethoxycarbonyl)(2-ethoxy-2-oxoethyl)amino)propanoyl)-1-(benzyloxycarbonylaminomethyl)-2,3,4,9-tetrahydro-1Hpyrido[3,4-b]indole-3-carboxylate

There total 6 articles about (1S,3S)-methyl 2-((S)-2-((9H-fluoren-9-ylmethoxycarbonyl)(2-ethoxy-2-oxoethyl)amino)propanoyl)-1-(benzyloxycarbonylaminomethyl)-2,3,4,9-tetrahydro-1Hpyrido[3,4-b]indole-3-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1427532-70-4
(1S,3S)-methyl 1-(benzyloxycarbonylaminomethyl)-2,3,4,9-tetrahydro-1H-pyrido[3,4-b]indole-3-carboxylate

: C₂₂H₂₂ClNO₅

: 1427532-76-0
(1S,3S)-methyl 2-((S)-2-((9H-fluoren-9-ylmethoxycarbonyl)(2-ethoxy-2-oxoethyl)amino)propanoyl)-1-(benzyloxycarbonylaminomethyl)-2,3,4,9-tetrahydro-1Hpyrido[3,4-b]indole-3-carboxylate

Guidance literature:: With 2,6-dimethylpyridine; In dichloromethane; at 0 - 20 ℃; Inert atmosphere;
DOI:10.3762/bjoc.9.17

Reference yield:

: 114790-39-5
benzyl N-(2,2-dimethoxyethyl)carbamate

: 1427532-76-0
(1S,3S)-methyl 2-((S)-2-((9H-fluoren-9-ylmethoxycarbonyl)(2-ethoxy-2-oxoethyl)amino)propanoyl)-1-(benzyloxycarbonylaminomethyl)-2,3,4,9-tetrahydro-1Hpyrido[3,4-b]indole-3-carboxylate

Guidance literature:: Multi-step reaction with 2 steps

1: trifluoroacetic acid / dichloromethane / -30 - 20 °C / Inert atmosphere

2: 2,6-dimethylpyridine / dichloromethane / 0 - 20 °C / Inert atmosphere

With 2,6-dimethylpyridine; trifluoroacetic acid; In dichloromethane; 1: |Pictet-Spengler Synthesis;
DOI:10.3762/bjoc.9.17

Reference yield:

: 1427532-75-9
(S)-2-((9H-fluoren-9-ylmethoxycarbonyl)(2-ethoxy-2-oxoethyl)amino)propanoic acid

: 1427532-76-0
(1S,3S)-methyl 2-((S)-2-((9H-fluoren-9-ylmethoxycarbonyl)(2-ethoxy-2-oxoethyl)amino)propanoyl)-1-(benzyloxycarbonylaminomethyl)-2,3,4,9-tetrahydro-1Hpyrido[3,4-b]indole-3-carboxylate

Guidance literature:: Multi-step reaction with 2 steps

1: thionyl chloride / dichloromethane / 5 h / 0 - 20 °C / Inert atmosphere

2: 2,6-dimethylpyridine / dichloromethane / 0 - 20 °C / Inert atmosphere

With 2,6-dimethylpyridine; thionyl chloride; In dichloromethane;
DOI:10.3762/bjoc.9.17