(S)-2-tert-Butoxycarbonylamino-4-methyl-pentanoic acid (E)-(1S,2R)-1-((E)-3-{(R)-2-(4-methoxy-phenyl)-1-[2-(2-trimethylsilanyl-ethoxycarbonyl)-ethylcarbamoyl]-ethylcarbamoyl}-allyl)-2-methyl-4-phenyl-but-3-enyl ester

Base Information

Chemical Name:(S)-2-tert-Butoxycarbonylamino-4-methyl-pentanoic acid (E)-(1S,2R)-1-((E)-3-{(R)-2-(4-methoxy-phenyl)-1-[2-(2-trimethylsilanyl-ethoxycarbonyl)-ethylcarbamoyl]-ethylcarbamoyl}-allyl)-2-methyl-4-phenyl-but-3-enyl ester
CAS No.:326473-64-7
Molecular Formula:C₄₄H₆₅N₃O₉Si
Molecular Weight:808.1
Hs Code.:

(S)-2-tert-Butoxycarbonylamino-4-methyl-pentanoic acid (E)-(1S,2R)-1-((E)-3-{(R)-2-(4-methoxy-phenyl)-1-[2-(2-trimethylsilanyl-ethoxycarbonyl)-ethylcarbamoyl]-ethylcarbamoyl}-allyl)-2-methyl-4-phenyl-but-3-enyl ester

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Chemical Property of (S)-2-tert-Butoxycarbonylamino-4-methyl-pentanoic acid (E)-(1S,2R)-1-((E)-3-{(R)-2-(4-methoxy-phenyl)-1-[2-(2-trimethylsilanyl-ethoxycarbonyl)-ethylcarbamoyl]-ethylcarbamoyl}-allyl)-2-methyl-4-phenyl-but-3-enyl ester

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Technology Process of (S)-2-tert-Butoxycarbonylamino-4-methyl-pentanoic acid (E)-(1S,2R)-1-((E)-3-{(R)-2-(4-methoxy-phenyl)-1-[2-(2-trimethylsilanyl-ethoxycarbonyl)-ethylcarbamoyl]-ethylcarbamoyl}-allyl)-2-methyl-4-phenyl-but-3-enyl ester

There total 4 articles about (S)-2-tert-Butoxycarbonylamino-4-methyl-pentanoic acid (E)-(1S,2R)-1-((E)-3-{(R)-2-(4-methoxy-phenyl)-1-[2-(2-trimethylsilanyl-ethoxycarbonyl)-ethylcarbamoyl]-ethylcarbamoyl}-allyl)-2-methyl-4-phenyl-but-3-enyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 162472-70-0
3-[(R)-2-[2-(Diethoxy-phosphoryl)-acetylamino]-3-(4-methoxy-phenyl)-propionylamino]-propionic acid 2-trimethylsilanyl-ethyl ester

: (S)-2-tert-Butoxycarbonylamino-4-methyl-pentanoic acid (E)-(1S,2R)-2-methyl-1-(2-oxo-ethyl)-4-phenyl-but-3-enyl ester

: 326473-64-7
(S)-2-tert-Butoxycarbonylamino-4-methyl-pentanoic acid (E)-(1S,2R)-1-((E)-3-{(R)-2-(4-methoxy-phenyl)-1-[2-(2-trimethylsilanyl-ethoxycarbonyl)-ethylcarbamoyl]-ethylcarbamoyl}-allyl)-2-methyl-4-phenyl-but-3-enyl ester

Guidance literature:: With sodium hydride; In tetrahydrofuran; at -10 ℃; for 1h;
DOI:10.1016/S0040-4020(00)00766-3

Reference yield:

: 13139-15-6,53296-34-7
N-tert-butoxycarbonyl-L-leucine

: 326473-64-7
(S)-2-tert-Butoxycarbonylamino-4-methyl-pentanoic acid (E)-(1S,2R)-1-((E)-3-{(R)-2-(4-methoxy-phenyl)-1-[2-(2-trimethylsilanyl-ethoxycarbonyl)-ethylcarbamoyl]-ethylcarbamoyl}-allyl)-2-methyl-4-phenyl-but-3-enyl ester

Guidance literature:: Multi-step reaction with 4 steps

1: 96 percent / DCC; DMAP / CH₂Cl₂ / 2 h / 20 °C

2: 92 percent / Me₂BBr / CH₂Cl₂ / 0.33 h / -78 °C

3: Dess-Martin periodinate / CH₂Cl₂ / 1.5 h / 20 °C

4: NaH / tetrahydrofuran / 1 h / -10 °C

With dmap; dimethylboron bromide; sodium hydride; Dess-Martin periodane; dicyclohexyl-carbodiimide; In tetrahydrofuran; dichloromethane; 1: Condensation / 2: Elimination / 3: Oxidation / 4: Horner-Emmons reaction;
DOI:10.1016/S0040-4020(00)00766-3

Reference yield:

: 172225-76-2
(E)-(3S,4R)-1-Methoxymethoxy-4-methyl-6-phenyl-hex-5-en-3-ol

: 326473-64-7
(S)-2-tert-Butoxycarbonylamino-4-methyl-pentanoic acid (E)-(1S,2R)-1-((E)-3-{(R)-2-(4-methoxy-phenyl)-1-[2-(2-trimethylsilanyl-ethoxycarbonyl)-ethylcarbamoyl]-ethylcarbamoyl}-allyl)-2-methyl-4-phenyl-but-3-enyl ester

Guidance literature:: Multi-step reaction with 4 steps

1: 96 percent / DCC; DMAP / CH₂Cl₂ / 2 h / 20 °C

2: 92 percent / Me₂BBr / CH₂Cl₂ / 0.33 h / -78 °C

3: Dess-Martin periodinate / CH₂Cl₂ / 1.5 h / 20 °C

4: NaH / tetrahydrofuran / 1 h / -10 °C

With dmap; dimethylboron bromide; sodium hydride; Dess-Martin periodane; dicyclohexyl-carbodiimide; In tetrahydrofuran; dichloromethane; 1: Condensation / 2: Elimination / 3: Oxidation / 4: Horner-Emmons reaction;
DOI:10.1016/S0040-4020(00)00766-3