8-((4-(4-chloro-3-(trifluoromethyl)phenoxy)phenethyl)amino)-1-methyl-3,4-dihydro-1H-pyrimido[1,6-a]pyrimidin-6(2H)-one trifluoroacetic acid salt

Base Information

Chemical Name:8-((4-(4-chloro-3-(trifluoromethyl)phenoxy)phenethyl)amino)-1-methyl-3,4-dihydro-1H-pyrimido[1,6-a]pyrimidin-6(2H)-one trifluoroacetic acid salt
CAS No.:1420367-42-5
Molecular Formula:C₂HF₃O₂*C₂₃H₂₂ClF₃N₄O₂
Molecular Weight:592.925
Hs Code.:

8-((4-(4-chloro-3-(trifluoromethyl)phenoxy)phenethyl)amino)-1-methyl-3,4-dihydro-1H-pyrimido[1,6-a]pyrimidin-6(2H)-one trifluoroacetic acid salt

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Chemical Property of 8-((4-(4-chloro-3-(trifluoromethyl)phenoxy)phenethyl)amino)-1-methyl-3,4-dihydro-1H-pyrimido[1,6-a]pyrimidin-6(2H)-one trifluoroacetic acid salt

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Technology Process of 8-((4-(4-chloro-3-(trifluoromethyl)phenoxy)phenethyl)amino)-1-methyl-3,4-dihydro-1H-pyrimido[1,6-a]pyrimidin-6(2H)-one trifluoroacetic acid salt

There total 3 articles about 8-((4-(4-chloro-3-(trifluoromethyl)phenoxy)phenethyl)amino)-1-methyl-3,4-dihydro-1H-pyrimido[1,6-a]pyrimidin-6(2H)-one trifluoroacetic acid salt which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 516481-95-1
4-{[4-chloro-3-(trifluoromethyl)phenyl]oxy}benzaldehyde

: 1420367-42-5
8-((4-(4-chloro-3-(trifluoromethyl)phenoxy)phenethyl)amino)-1-methyl-3,4-dihydro-1H-pyrimido[1,6-a]pyrimidin-6(2H)-one trifluoroacetic acid salt

Guidance literature:: Multi-step reaction with 4 steps

1.1: ammonium acetate; acetic acid / 5 h / 120 °C

2.1: sodium tetrahydroborate / isopropyl alcohol; chloroform / 20 °C / Molecular sieve

3.1: ammonium formate; zinc / water; methanol / 2 h / 80 °C

4.1: triethylamine / N,N-dimethyl-formamide / 3 h / 140 °C / Microwave irradiation

4.2: pH Ca_. 5

With sodium tetrahydroborate; ammonium acetate; ammonium formate; acetic acid; triethylamine; zinc; In methanol; chloroform; water; N,N-dimethyl-formamide; isopropyl alcohol;

Reference yield:

: 1380429-33-3
(E)-1-chloro-4-(4-(2-nitrovinyl)phenoxy)-2-(trifluoromethyl)benzene

: 1420367-42-5
8-((4-(4-chloro-3-(trifluoromethyl)phenoxy)phenethyl)amino)-1-methyl-3,4-dihydro-1H-pyrimido[1,6-a]pyrimidin-6(2H)-one trifluoroacetic acid salt

Guidance literature:: Multi-step reaction with 3 steps

1.1: sodium tetrahydroborate / isopropyl alcohol; chloroform / 20 °C / Molecular sieve

2.1: ammonium formate; zinc / water; methanol / 2 h / 80 °C

3.1: triethylamine / N,N-dimethyl-formamide / 3 h / 140 °C / Microwave irradiation

3.2: pH Ca_. 5

With sodium tetrahydroborate; ammonium formate; triethylamine; zinc; In methanol; chloroform; water; N,N-dimethyl-formamide; isopropyl alcohol;

Reference yield:

: 1380429-34-4
1-chloro-4-(4-(2-nitroethyl)phenoxy)-2-(trifluoromethyl)benzene

: 1420367-42-5
8-((4-(4-chloro-3-(trifluoromethyl)phenoxy)phenethyl)amino)-1-methyl-3,4-dihydro-1H-pyrimido[1,6-a]pyrimidin-6(2H)-one trifluoroacetic acid salt

Guidance literature:: Multi-step reaction with 2 steps

1.1: ammonium formate; zinc / water; methanol / 2 h / 80 °C

2.1: triethylamine / N,N-dimethyl-formamide / 3 h / 140 °C / Microwave irradiation

2.2: pH Ca_. 5

With ammonium formate; triethylamine; zinc; In methanol; water; N,N-dimethyl-formamide;