N-benzyl-2-ethylhexanamide

Base Information

• Chemical Name: N-benzyl-2-ethylhexanamide
• CAS No.: 349120-32-7
• Molecular Formula: C₁₅H₂₃NO
• Molecular Weight: 233.354
• Mol file: 349120-32-7.mol

Synonyms:

Chemical Property of N-benzyl-2-ethylhexanamide

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of N-benzyl-2-ethylhexanamide

There total 6 articles about N-benzyl-2-ethylhexanamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

(S)-2-Ethyl-3-(toluene-4-sulfonyl)-hexanoic acid benzylamide (879881-82-0) → (R)-2-Ethyl-hexanoic acid benzylamide (879881-86-4,349120-32-7)

Guidance literature:

With sodium amalgam; In methanol; at 0 ℃; for 2h;

DOI:10.1080/00397910500374740

Reference yield:

(R)-5-Chloro-5-(toluene-4-sulfonyl)-octan-4-one (879881-79-5) → (R)-2-Ethyl-hexanoic acid benzylamide (879881-86-4,349120-32-7)

Guidance literature:

Multi-step reaction with 2 steps

1: 97 percent / NaH / tetrahydrofuran / 2.5 h / 0 °C

2: 90 percent / Na amalgam / methanol / 2 h / 0 °C

With sodium amalgam; sodium hydride; In tetrahydrofuran; methanol; 1: Favorskii asymmetric rearrangement;

DOI:10.1080/00397910500374740

Reference yield:

(R)-5-Chloro-5-(toluene-4-sulfonyl)-octan-4-ol (879881-77-3) → (R)-2-Ethyl-hexanoic acid benzylamide (879881-86-4,349120-32-7)

Guidance literature:

Multi-step reaction with 3 steps

1: 97 percent / NaH / tetrahydrofuran / 2.5 h / 0 °C

2: 90 percent / Na amalgam / methanol / 2 h / 0 °C

With sodium amalgam; sodium hydride; In tetrahydrofuran; methanol; 1: Swern oxidation / 2: Favorskii asymmetric rearrangement;

DOI:10.1080/00397910500374740

upstream raw materials:

benzylamine

2-ethylhexanoic acid chloride

(S)-2-Ethyl-3-(toluene-4-sulfonyl)-hexanoic acid benzylamide

ethylmagnesium iodide