4'-hydroxy-2-{[3-(4-methoxyphenyl)-1-methylpropyl]amino}-3'-(methylthio)acetophenone 4'-benzoate hydrobromide

Base Information

• Chemical Name: 4'-hydroxy-2-{[3-(4-methoxyphenyl)-1-methylpropyl]amino}-3'-(methylthio)acetophenone 4'-benzoate hydrobromide
• CAS No.: 66264-76-4
• Molecular Formula: BrH*C₂₇H₂₉NO₄S
• Molecular Weight: 544.51
• Mol file: 66264-76-4.mol

Synonyms:

Chemical Property of 4'-hydroxy-2-{[3-(4-methoxyphenyl)-1-methylpropyl]amino}-3'-(methylthio)acetophenone 4'-benzoate hydrobromide

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 4'-hydroxy-2-{[3-(4-methoxyphenyl)-1-methylpropyl]amino}-3'-(methylthio)acetophenone 4'-benzoate hydrobromide

There total 7 articles about 4'-hydroxy-2-{[3-(4-methoxyphenyl)-1-methylpropyl]amino}-3'-(methylthio)acetophenone 4'-benzoate hydrobromide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

4-(2-bromoacetyl)-3-(methylthio)phenyl acetate (66264-75-3) + (+)-(R)-1-Methyl-3-(4-methoxyphenyl)-1-propylamine (51062-15-8) → 4'-hydroxy-2-{[3-(4-methoxyphenyl)-1-methylpropyl]amino}-3'-(methylthio)acetophenone 4'-benzoate hydrobromide (66264-76-4,66264-97-9,66265-65-4)

Guidance literature:

Reference yield:

4-acetyl-2-(methylthio)phenyl benzoate (66264-74-2) → 4'-hydroxy-2-{[3-(4-methoxyphenyl)-1-methylpropyl]amino}-3'-(methylthio)acetophenone 4'-benzoate hydrobromide (66264-76-4,66264-97-9,66265-65-4)

Guidance literature:

Multi-step reaction with 2 steps

1: nitrogen; bromine / benzene

2: triethylamine / Eu(TFC)3 / Isopropyl acetate; N,N-dimethyl-formamide

With nitrogen; bromine; triethylamine; Eu(TFC)3; In Isopropyl acetate; N,N-dimethyl-formamide; benzene;

Reference yield:

2-(methylsulfenyl)phenol (1073-29-6) → 4'-hydroxy-2-{[3-(4-methoxyphenyl)-1-methylpropyl]amino}-3'-(methylthio)acetophenone 4'-benzoate hydrobromide (66264-76-4,66264-97-9,66265-65-4)

Guidance literature:

Multi-step reaction with 4 steps

1: aluminium trichloride / nitrobenzene

2: pyridine; water

3: nitrogen; bromine / benzene

4: triethylamine / Eu(TFC)3 / Isopropyl acetate; N,N-dimethyl-formamide

With nitrogen; bromine; triethylamine; aluminium trichloride; Eu(TFC)3; In pyridine; Isopropyl acetate; water; nitrobenzene; N,N-dimethyl-formamide; benzene;

upstream raw materials:

4-(2-bromoacetyl)-3-(methylthio)phenyl acetate

(+)-(R)-1-Methyl-3-(4-methoxyphenyl)-1-propylamine

2-(methylsulfenyl)phenol

4'-hydroxy-3'-mercaptoacetophenone

Refernces

• 1、 -. "α-{[(Arylalkyl)amino]alkyl}-4-hydroxy-3-(lower-alkylsulfinyl)benzenemethanols". . . Retrieved 2008/06/13.